Evidence map›Paper›PMID 36247911›Full record

ArticleMovement disorders clinical practice2022

Aggression Towards Caregivers in Parkinson's Disease and Related Disorders: A Mixed Methods Study.

Zachary A Macchi, Sandhya Seshadri, Roman Ayele, Meredith Bock, Judith Long, Heather Coats, Janis Miyasaki, Steven Z Pantilat, Maya Katz, Elizabeth J Santos and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Movement disorders clinical practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 2 countries.

Zachary A MacchiBehavioral Neurology|Neuropalliative Sections, Department of Neurology University of Colorado Anschutz Aurora Colorado USA.ORCID https://orcid.org/0000-0001-8900-9500
Sandhya SeshadriDepartment of Neurology and Medicine University of Rochester Medical Center Rochester New York USA.
Roman AyeleDenver-Seattle Center of Innovation at Eastern Colorado VA Healthcare System Denver Colorado USA.
Meredith BockWeill Institute for Neuroscience University of California, San Francisco San Francisco California USA.ORCID https://orcid.org/0000-0002-8704-916X
Judith LongDivision of Palliative Medicine, Department of Medicine University of California, San Francisco California USA.
Heather CoatsCollege of Nursing University of Colorado Anschutz Aurora Colorado USA.
Janis MiyasakiDivision of Neurology, Department of Medicine University of Alberta Edmonton Alberta Canada.ORCID https://orcid.org/0000-0002-6372-6007
Steven Z PantilatDivision of Palliative Medicine, Department of Medicine University of California, San Francisco California USA.
Maya KatzDepartment of Neurology and Neurological Sciences Stanford University School of Medicine Palo Alto California USA.
Elizabeth J SantosDivision of Geriatric Mental Health and Memory Care University of Rochester School of Medicine and Dentistry Rochester New York USA.
Stefan H SillauBehavioral Neurology|Neuropalliative Sections, Department of Neurology University of Colorado Anschutz Aurora Colorado USA.
Hillary D LumDivision of Geriatric Medicine, Department of Medicine University of Colorado School of Medicine Aurora Colorado USA.
Benzi M KlugerBehavioral Neurology|Neuropalliative Sections, Department of Neurology University of Colorado Anschutz Aurora Colorado USA.
University of California, San Francisco · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Rochester Medical Center · USStanford University · USUniversity of Alberta · CAUniversity of Colorado Denver · USUniversity of Rochester · USVA Eastern Colorado Health Care System · US

Funding

More than a Movement Disorder: Applying Palliative Care to Parkinson's Disease and Lewy Body DementiasR01NR016037 · NINR · UNIVERSITY OF ROCHESTER · PI KLUGER, BENZI M · 2016 to 2025
$6.5M
Multidisciplinary Research Training in Palliative CareT32AG044296 · NIA · UNIVERSITY OF COLORADO DENVER · PI STACY M FISCHER, JEAN S KUTNER · 2014 to 2026
$3.3M
Advancing Palliative Care for Older Adults Affected by Neurodegenerative Disease: Parkinsons disease, Alzheimers disease and Related DementiasK02AG062745 · NIA · UNIVERSITY OF ROCHESTER · PI KLUGER, BENZI M · 2020 to 2024
$711k
NIA NIH HHS K02 AG062745NIA NIH HHS T32 AG044296NINR NIH HHS R01 NR016037
6 · The paper itself

Abstract

Background: Aggression is one manifestation of behavioral disturbances in neurodegenerative disease with emerging literature suggesting a high prevalence in Parkinson's disease and related disorders (PDRD). Objectives: Our aim was to describe characteristics, associated factors, and consequences of aggression towards caregivers in PDRD. Methods: This is a convergent mixed methods study, leveraging data from 296 PDRD patient-caregiver dyads in a clinical trial of palliative care and semi-structured interviews with a subgroup of 14 caregivers who reported aggression. The primary outcome was baseline caregiver-reported aggression. Using multivariate linear regression, baseline dyad characteristics (eg, measures of disease, psychosocial issues, caregiver strain) were examined to identify factors associated with aggression. Thematic analysis of interviews was used to augment these findings. Results: Associated variables included disease duration ( Conclusions: Aggression in PDRD is driven by diverse factors (eg, grief, fluctuations in cognition) with serious consequences for caregivers. Neurologists and movement specialists should consider screening for aggression while prioritizing caregiver education and wellbeing.

Indexed as

aggressionbehavioral disturbancescaregiversParkinson's diseasepsychosocial issues

Identifiers

PMID36247911
PMCPMC9547131
OpenAlexW4292602920

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.