Evidence map›Paper›PMID 36247832›Full record

ArticleChild development perspectives2022

The Bucharest Early Intervention Project: Adolescent mental health and adaptation following early deprivation.

Mark Wade, Jill Parsons, Kathryn L Humphreys, Katie A McLaughlin, Margaret A Sheridan, Charles H Zeanah, Charles A Nelson, Nathan A Fox

Abstract read
In one paragraph

Article in Child development perspectives, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mark WadeUniversity of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-4643-8465
Jill ParsonsWilliams College, Williamstown, Massachusetts, USA.
Kathryn L HumphreysVanderbilt University, Nashville, Tennessee, USA.
Katie A McLaughlinHarvard University, Cambridge, Massachusetts, USA.
Margaret A SheridanUniversity of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Charles H ZeanahTulane University School of Medicine, New Orleans, Louisiana, USA.
Charles A NelsonHarvard Graduate School of Education, Boston Children's Hospital of Harvard Medical School, Boston, Massachusetts, USA.
Nathan A FoxUniversity of Maryland, College Park, Maryland, USA.

Funding

Neurodevelopmental Mechanisms Underlying Stress Vulnerability during AdolescenceR37MH119194 · NIMH · HARVARD UNIVERSITY · PI Katie McLaughlin · 2020 to 2026
$10.6M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
The Relation Between Early Psychosocial Deprivation and Mental Health at 12 YearsR01MH091363 · NIMH · UNIV OF MARYLAND, COLLEGE PARK · PI FOX, NATHAN A, NELSON, CHARLES ALEXANDER · 2010 to 2024
$9.2M
Deprivation and Threat: Dimensions of Early Experience and Neural DevelopmentR01MH106482 · NIMH · UNIVERSITY OF WASHINGTON · PI MCLAUGHLIN, KATIE · 2016 to 2020
$3.1M
NICHD NIH HHS P2C HD050924NICHD NIH HHS P50 HD105351NIMH NIH HHS R01 MH091363NIMH NIH HHS R01 MH106482NIMH NIH HHS R37 MH119194
6 · The paper itself

Abstract

Over the last 20 years, we have learned much about the extent to which early-life deprivation affects the mental health of children and adolescents. This body of evidence comes predominantly from studies of children raised in institutional care. The Bucharest Early Intervention Project (BEIP) is the only randomized controlled trial designed to evaluate whether the transition to family-based foster care early in development can ameliorate the long-term impact of institutional deprivation on psychopathology during vulnerable developmental windows such as adolescence. In this review, we detail the extent to which early deprivation affects mental health during this period, the capacity of family-based care to facilitate recovery from early deprivation, and the mechanisms underpinning these effects spanning social-emotional, cognitive, stress, and neurobiological domains. We end by discussing the implications and directions for the BEIP and other studies of youth raised in institutions.

Indexed as

early-life deprivationfoster care interventioninstitutional raising

Identifiers

PMID36247832
PMCPMC9555391

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.