ArticleFrontiers in neurology2022
Hyperhomocysteinemia and intracranial aneurysm: A mendelian randomization study.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- DNA methylation-estimated phenotypes, telomere length, aging and risk of intracranial aneurysms: Evidence from genetic studies.IBRO neuroscience reports · 2026Article
- The causal role of homocysteine in multiple diseases: a systematic review of Mendelian randomization studies.Nutrition & metabolism · 2025Review
- A Mendelian randomisation, propensity score matching study to investigate causal association between serum homocysteine and intracranial aneurysm.Stroke and vascular neurology · 2024Observational
- Mendelian randomization analyses for the causal relationship between early age at first sexual intercourse, early age at first live birth, and postpartum depression in pregnant women.Frontiers in psychiatry · 2024Article
- The evolution of Big Data in neuroscience and neurology.Journal of big data · 2023Article
- Mendelian randomization study to investigate the causal relationship between plasma homocysteine and chronic obstructive pulmonary disease.World journal of emergency medicine · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
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Abstract
Objective: To investigate the link between genetic variants associated with plasma homocysteine levels and risk of intracranial aneurysm (IA) using two-sample Mendelian randomization. Methods: We used single-nucleotide polymorphisms associated with human plasma homocysteine levels as instrumental variables for the primary analysis in a genome-wide association study of 44,147 subjects of European ancestry. Summary-level statistics were obtained for 79,429 individuals, including 7,495 IA cases and 71,934 controls. To enhance validity, five different Mendelian randomization methods (MR-Egger, weighted median, inverse variance weighted, simple mode, and weighted mode) were used for the analyses. Results: The inverse variance weighted analysis method produced Conclusion: Using gene-related instrumental variables, the Mendelian randomization analyses demonstrated a lack of an association between plasma homocysteine levels and IAs or aneurysmal subarachnoid hemorrhage.
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