ArticleBrain & spine2021
The association of patient age with postoperative morbidity and mortality following resection of intracranial tumors.
Article in Brain & spine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- Age at time of surgery does not influence outcome in idiopathic normal pressure hydrocephalus - a national quality registry study of 3082 patients.Acta neurochirurgica · 2025Article
- Determinants of poor prognosis after surgery for glioblastoma: A retrospective analysis of predictors of morbidity and mortality in a low-middle income country.Pakistan journal of medical sciences · 2025Article
- Timing of complications following stereotactic brain biopsy: implications for same-day discharge feasibility.Journal of neuro-oncology · 2025Article
- The impact of sociodemographic factors and surgical modalities on deep brain stimulation for Parkinson's disease.Surgical neurology international · 2025Article
- Neurosurgery outcomes and complications in a monocentric 7-year patient registry.Brain & spine · 2022Article
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Authors and funding
35 authors.
Funding
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Abstract
Introduction: The postoperative functional status of patients with intracranial tumors is influenced by patient-specific factors, including age. Research question: This study aimed to elucidate the association between age and postoperative morbidity or mortality following the resection of brain tumors. Material and methods: A multicenter database was retrospectively reviewed. Functional status was assessed before and 3-6 months after tumor resection by the Karnofsky Performance Scale (KPS). Uni- and multivariable linear regression were used to estimate the association of age with postoperative change in KPS. Logistic regression models for a ≥10-point decline in KPS or mortality were built for patients ≥75 years. Results: The total sample of 4864 patients had a mean age of 56.4 ± 14.4 years. The mean change in pre-to postoperative KPS was -1.43. For each 1-year increase in patient age, the adjusted change in postoperative KPS was -0.11 (95% CI -0.14 - - 0.07). In multivariable analysis, patients ≥75 years had an odds ratio of 1.51 to experience postoperative functional decline (95%CI 1.21-1.88) and an odds ratio of 2.04 to die (95%CI 1.33-3.13), compared to younger patients. Discussion: Patients with intracranial tumors treated surgically showed a minor decline in their postoperative functional status. Age was associated with this decline in function, but only to a small extent. Conclusion: Patients ≥75 years were more likely to experience a clinically meaningful decline in function and about two times as likely to die within the first 6 months after surgery, compared to younger patients.
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