Evidence map›Paper›PMID 36247296›Full record

ArticleAmerican journal of translational research2022

Relationship between microRNA expression and inflammatory factors in patients with both type 2 diabetes mellitus and periodontal disease.

Lu Liu, Zunsheng Xiao, Wencui Ding, Chao Wen, Chao Ge, Ke Xu, Sumin Cao

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
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  6. Review
  7. Article
  8. Lower Serum IL-10 Linked to Oral Manifestations in Diabetes Patients.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025
    Article
  9. Review
  10. Review
  11. Review
  12. Role of microRNAs in Diabetes-Associated Periodontitis: A Scoping Review.Journal of International Society of Preventive & Community Dentistry
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lu LiuDepartment of Stomatology, Cangzhou Central Hospital Cangzhou, Hebei, China.
Zunsheng XiaoDepartment of Stomatology, Cangzhou Central Hospital Cangzhou, Hebei, China.
Wencui DingThe First Department of Endocrine Diabetes, Cangzhou Central Hospital Cangzhou, Hebei, China.
Chao WenDepartment of Clinical Laboratoy, Cangzhou Central Hospital Cangzhou, Hebei, China.
Chao GeDepartment of Stomatology, Cangzhou Central Hospital Cangzhou, Hebei, China.
Ke XuDepartment of Stomatology, Cangzhou Central Hospital Cangzhou, Hebei, China.
Sumin CaoDepartment of Stomatology, Cangzhou Central Hospital Cangzhou, Hebei, China.
Cangzhou Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the expression of single-stranded microRNAs (miRNAs) in serum and gingival crevicular fluid of patients with type 2 diabetes mellitus (T2DM) complicated by periodontal disease and its correlation with inflammatory factors.

methodsTwenty-six periodontitis patients without diabetes mellitus (periodontal group), 24 patients with T2DM (T2DM group), 22 patients with both T2DM and periodontal disease (comorbid group), and 25 healthy individuals without a history of periodontal disease (healthy group) were recruited respectively. Serum and gingival crevicular fluid specimens were collected to detect the expression levels of miRNAs and inflammatory factors including serum tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), and transforming growth factor-β (TGF-β), and their correlations were also investigated.

resultsEleven miRNAs were detected in the gingival crevicular tissue of all subjects. The expression of miR-223 and miR-200b in serum and gingival crevicular fluid was elevated higher in the comorbid group than in the other three groups (

conclusionsOur findings indicate a close link between the levels of miR-223 and miR-200b in serum and gingival crevicular fluid and susceptibility to T2DM as well as the pathogenesis of periodontal disease.

Indexed as

gingival crevicular fluidperiodontal diseasesingle-stranded microRNAT2DM

Identifiers

PMID36247296
PMCPMC9556472
OpenAlexW4306668005

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.