ArticleAmerican journal of translational research2022
Effect of dexmedetomidine on intracranial pressure in patients undergoing gynecological laparoscopic surgery in Trendelenburg position through ultrasonographic measurement of optic nerve sheath diameter.
Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Ultrasound Measurement of Dynamic Changes in Optic Nerve Sheath Diameter During Liposuction Surgery: A Prospective Clinical Trial.Aesthetic plastic surgery · 2026Trial
- Effect of dexmedetomidine combined with magnesium sulphate on intracranial tension in patients with severe pre-eclampsia using ultrasonographic optic nerve sheath Diameter - A randomised clinical trial.Indian journal of anaesthesia · 2025Article
- Intracranial pressure estimated non-invasively and postoperative outcomes in surgery in the Trendelenburg position with pneumoperitoneum.Journal of anesthesia, analgesia and critical care · 2025Review
- Deep learning based optic nerve sheath diameter characterization and structure quantification on transorbital ultrasound images.Frontiers in medicine · 2025Article
- Effect of dexmedetomidine on pulmonary function in obese patients undergoing laparoscopic surgery.Perioperative medicine (London, England) · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effect of dexmedetomidine on intracranial pressure (ICP) in patients undergoing gynecological laparoscopic surgery in Trendelenburg position through ultrasonographic measurement of optic nerve sheath diameter (ONSD).
methodsNinety patients underwent total laparoscopic hysterectomy were selected as research subjects in this prospective study. These patients were divided into a dexmedetomidine group (n=45) and a control group (n=45) using a random number table. The dexmedetomidine group was pumped with 0.5 μg/kg dexmedetomidine (20041731, Yangtze River Pharmaceutical Group, China) 10 min before the anesthesia induction, followed by a continuous pump of 0.5 μg/(kg·h) until the end of the surgery, and the control group was pumped with 0.5 μg/(kg·h) 0.9% sodium chloride solution. Patients in both groups were assisted with mechanical ventilator after endotracheal intubation by rapid induction. Intraoperatively, the pneumoperitoneum pressure was maintained at 14 mmHg, and the bispectral index was maintained at 40 to 60. We recorded ONSD measured with ultrasonography in both groups at 5 min before induction of anesthesia in supine position (T1), 5 min after CO
resultsThere were significant differences in ONSD at T2 ((4.77±0.14) mm vs. (4.98±0.13) mm), T3 ((5.19±0.15) mm vs. (5.53±0.14) mm), T4 ((5.10±0.11) mm vs. (5.27±0.13) mm) and T5 ((4.71±0.12) mm vs. (4.4±0.16) mm) between the two groups (all P<0.05), and obvious differences were also found within groups when comparing the ONSD at T2-T5 to that at T1 (P<0.05). There were also significant differences in SjvO
conclusionDexmedetomidine can effectively decrease the occurence of increased ICP in patients undergoing gynecological laparoscopic surgery in Trendelenburg position, improve brain oxygen metabolism, and reduce the incidences of postoperative dizziness, nausea and vomiting as well as headache (China Clinical Trials Registration Center, registration number: ChiCTR2100052046, https://www.chictr.org.cn).
Indexed as
Identifiers
36247291PMC9556444W4306669526What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.