Evidence map›Paper›PMID 36247217›Full record

ReviewNature reviews. Physics2022

On scientific understanding with artificial intelligence.

Mario Krenn, Robert Pollice, Si Yue Guo, Matteo Aldeghi, Alba Cervera-Lierta, Pascal Friederich, Gabriel Dos Passos Gomes, Florian Häse, Adrian Jinich, AkshatKumar Nigam and 2 more

Abstract readReview
In one paragraph

Review in Nature reviews. Physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed.

  1. Review
  2. AI-driven robotics for optics.Science advances · 2026
    Article
  3. Article
  4. Explainable AI: learning from the learners.Nature communications · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. AI for scientific discovery is a social problem.Patterns (New York, N.Y.) · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Heavy-tailed update distributions arise from information-driven self-organization in nonequilibrium learning.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Review

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mario KrennMax Planck Institute for the Science of Light (MPL), Erlangen, Germany.
Robert PolliceChemical Physics Theory Group, Department of Chemistry, University of Toronto, Toronto, Ontario Canada.
Si Yue GuoChemical Physics Theory Group, Department of Chemistry, University of Toronto, Toronto, Ontario Canada.
Matteo AldeghiChemical Physics Theory Group, Department of Chemistry, University of Toronto, Toronto, Ontario Canada.
Alba Cervera-LiertaChemical Physics Theory Group, Department of Chemistry, University of Toronto, Toronto, Ontario Canada.
Pascal FriederichChemical Physics Theory Group, Department of Chemistry, University of Toronto, Toronto, Ontario Canada.
Gabriel Dos Passos GomesChemical Physics Theory Group, Department of Chemistry, University of Toronto, Toronto, Ontario Canada.
Florian HäseChemical Physics Theory Group, Department of Chemistry, University of Toronto, Toronto, Ontario Canada.
Adrian JinichDivision of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medical College, New York, USA.
AkshatKumar NigamChemical Physics Theory Group, Department of Chemistry, University of Toronto, Toronto, Ontario Canada.
Zhenpeng YaoChemical Physics Theory Group, Department of Chemistry, University of Toronto, Toronto, Ontario Canada.ORCID 0000-0001-8286-8257
Alán Aspuru-GuzikChemical Physics Theory Group, Department of Chemistry, University of Toronto, Toronto, Ontario Canada.ORCID 0000-0002-8277-4434

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An oracle that correctly predicts the outcome of every particle physics experiment, the products of every possible chemical reaction or the function of every protein would revolutionize science and technology. However, scientists would not be entirely satisfied because they would want to comprehend how the oracle made these predictions. This is scientific understanding, one of the main aims of science. With the increase in the available computational power and advances in artificial intelligence, a natural question arises: how can advanced computational systems, and specifically artificial intelligence, contribute to new scientific understanding or gain it autonomously? Trying to answer this question, we adopted a definition of 'scientific understanding' from the philosophy of science that enabled us to overview the scattered literature on the topic and, combined with dozens of anecdotes from scientists, map out three dimensions of computer-assisted scientific understanding. For each dimension, we review the existing state of the art and discuss future developments. We hope that this Perspective will inspire and focus research directions in this multidisciplinary emerging field.

Indexed as

Physical chemistryQuantum physics

Identifiers

PMID36247217
PMCPMC9552145

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.