ArticleGeneral psychiatry2022
Handgrip strength and the risk of major depressive disorder: a two-sample Mendelian randomisation study.
Article in General psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Cumulative handgrip strength and trajectories of depressive symptoms in older adults: evidence from two cohort studies.BMC public health · 2025Article
- Physical Strength Is Not Associated With Facial Sexual Dimorphism and Asymmetry in Either Czechs or Cameroonians.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- National trends of mental health and service utilisation among international students in the USA, 2015-2024.General psychiatry · 2025Article
- Assessment of the bidirectional causal association between frailty and depression: A Mendelian randomization study.Journal of cachexia, sarcopenia and muscle · 2023Article
- Causal associations between major depressive disorder and COVID-19.General psychiatry · 2023Article
- Shared genetics and bidirectional causal relationships between type 2 diabetes and attention-deficit/hyperactivity disorder.General psychiatry · 2023Article
- Special issue for psychosomatic medicine.General psychiatry · 2022Article
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Authors and funding
3 authors.
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Abstract
Background: Major depressive disorder (MDD) is a common psychiatric disease and a leading cause of disability worldwide. Handgrip strength (HGS) as an objective physical fitness test is a practical index for identifying many diseases. Previous studies drew different conclusions about the relationship between HGS and MDD. Aims: We aim to explore whether HGS has an effect on the risk of MDD. Methods: HGS-related single-nucleotide polymorphisms identified by a genome-wide association study were used as instrumental variables in this Mendelian randomisation (MR) study. Summary data on MDD were obtained from the Psychiatric Genomics Consortium. Four methods were applied, including inverse variance weighted (IVW), MR Egger, weighted median and weighted mode. Additional sensitivity analyses, including leave-one-out, heterogeneity test, pleiotropy test and confounders identification, were conducted to test the robustness of our results. Results: Each 1 kg increase in left HGS is associated with a 21.95% reduction in the risk of MDD (OR Conclusions: Increased left HGS is associated with a reduced risk of MDD. In the future, it may be used as an index for the clinical screening, observation and treatment of MDD.
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