Evidence map›Paper›PMID 36246978›Full record

ArticleBioMed research international2022

Systematic Analysis of CXC Chemokine-Vascular Endothelial Growth Factor A Network in Colonic Adenocarcinoma from the Perspective of Angiogenesis.

Yongli Situ, Xiaoyong Lu, Yongshi Cui, Qinying Xu, Li Deng, Hao Lin, Zheng Shao, Jv Chen

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Regulation of VEGF-A expression and VEGF-A-targeted therapy in malignant tumors.Journal of cancer research and clinical oncology · 2024
    Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Yongli SituDepartment of Parasitology, Guangdong Medical University, Zhanjiang, 524023 Guangdong, China.ORCID https://orcid.org/0000-0003-2244-115X
Xiaoyong LuDepartment of Parasitology, Guangdong Medical University, Zhanjiang, 524023 Guangdong, China.
Yongshi CuiDepartment of Parasitology, Guangdong Medical University, Zhanjiang, 524023 Guangdong, China.
Qinying XuDepartment of Parasitology, Guangdong Medical University, Zhanjiang, 524023 Guangdong, China.
Li DengDepartment of Parasitology, Guangdong Medical University, Zhanjiang, 524023 Guangdong, China.
Hao LinOrthopedic Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524023 Guangdong, China.
Zheng ShaoDepartment of Parasitology, Guangdong Medical University, Zhanjiang, 524023 Guangdong, China.
Jv ChenDepartment of Pharmacy, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001 Guangdong, China.ORCID https://orcid.org/0000-0001-5083-2129
Guangdong Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Tumor angiogenesis plays a vital role in tumorigenesis, proliferation, and metastasis. Recently, vascular endothelial growth factor A ( Methods: In this study, we analyzed gene expression and regulation, prognostic value, target prediction, and immune infiltrates related to the CXC chemokine-VEGFA network in patients with COAD using multiple databases (cBioPortal, UALCAN, Human Protein Atlas, GeneMANIA, GEPIA, TIMER (version 2.0), TRRUST (version 2), LinkedOmics, and Metascape). Results: Our results showed that Conclusions: This study revealed that the CXC chemokine-VEGFA network might act as a prognostic biomarker for patients with COAD. Moreover, our study provides new therapeutic targets for COAD, serving as a reference for further research in the future.

Indexed as

AdenocarcinomaChemokines, CXCColonic NeoplasmsMicroRNAsVascular Endothelial Growth Factor ABiomarkersHumansTranscription FactorsBiomarkersChemokines, CXCMicroRNAsTranscription FactorsVascular Endothelial Growth Factor A

Identifiers

PMID36246978
PMCPMC9553499
OpenAlexW4301185255

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.