Evidence map›Paper›PMID 36246974›Full record

ArticleBioMed research international2022

Downregulation of Matriptase Inhibits Porphyromonas gingivalis Lipopolysaccharide-Induced Matrix Metalloproteinase-1 and Proinflammatory Cytokines by Suppressing the TLR4/NF-

Jeong-Mi Kim, Eun-Mi Noh, Yong-Ouk You, Min Seuk Kim, Young-Rae Lee

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Heliyon · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jeong-Mi KimDepartment of Biochemistry, Jeonbuk National University Medical School, Jeonju-si, Jeollabuk-do 54896, Republic of Korea.ORCID https://orcid.org/0000-0002-7517-7586
Eun-Mi NohDepartment of Oral Biochemistry, And Institute of Biomaterials-Implant, College of Dentistry, Wonkwang University, Iksan City, Jeonbuk 54538, Republic of Korea.ORCID https://orcid.org/0000-0003-3782-8779
Yong-Ouk YouDepartment of Oral Biochemistry, And Institute of Biomaterials-Implant, College of Dentistry, Wonkwang University, Iksan City, Jeonbuk 54538, Republic of Korea.ORCID https://orcid.org/0000-0002-7754-3033
Min Seuk KimDepartment of Oral Physiology, And Institute of Biomaterial-Implant, College of Dentistry, Wonkwang University, Iksan City, Jeonbuk 54538, Republic of Korea.ORCID https://orcid.org/0000-0003-0071-0830
Young-Rae LeeDepartment of Oral Biochemistry, And Institute of Biomaterials-Implant, College of Dentistry, Wonkwang University, Iksan City, Jeonbuk 54538, Republic of Korea.ORCID https://orcid.org/0000-0002-2119-2609
Wonkwang University · KRJeonbuk National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Matriptases are cell surface proteolytic enzymes belonging to the type II transmembrane serine protease family that mediate inflammatory skin disorders and cancer progression. Matriptases may affect the development of periodontitis via protease-activated receptor-2 activity. However, the cellular mechanism by which matriptases are involved in periodontitis is unknown. In this study, we examined the antiperiodontitis effects of matriptase on

Indexed as

FibroblastsMatrix Metalloproteinase 1PeriodontitisSerine EndopeptidasesCytokinesDown-RegulationHumansInterleukin-1Interleukin-6Interleukin-8LipopolysaccharidesNF-kappa BPorphyromonas gingivalisReceptors, Proteinase-ActivatedRNA, MessengerRNA, Small InterferingCytokinesInterleukin-1Interleukin-6Interleukin-8LipopolysaccharidesmatriptaseMatrix Metalloproteinase 1NF-kappa BReceptors, Proteinase-ActivatedRNA, MessengerRNA, Small InterferingSerine EndopeptidasesTLR4 protein, humanToll-Like Receptor 4Transforming Growth Factor betaTumor Necrosis Factor-alpha

Identifiers

PMID36246974
PMCPMC9553488
OpenAlexW4301373270

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.