Evidence map›Paper›PMID 36246950›Full record

ArticleOphthalmology science2021

Assessing Foveal Structure in Individuals with

Gelique D Ayala, Rachel E Linderman, Robert K Valenzuela, Erica N Woertz, Murray Brilliant, Sergey Tarima, Joseph Carroll

Open access · goldAbstract read
In one paragraph

Article in Ophthalmology science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Article
  6. Oculocutaneous albinism in a patient with anAsian biomedicine : research, reviews and news · 2025
    Article
  7. Article
  8. In Vivo Assessment of Retinal Phenotypes in Axenfeld-Rieger Syndrome.Investigative ophthalmology & visual science · 2024
    Article
  9. Foveal Curvature and Its Associations in UK Biobank Participants.Investigative ophthalmology & visual science · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Gelique D AyalaSchool of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
Rachel E LindermanOphthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin.
Robert K ValenzuelaCenter for Precision Medicine, Marshfield Clinic Research Institute, Marshfield, Wisconsin.
Erica N WoertzSchool of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
Murray BrilliantWaisman Center, University of Wisconsin-Madison, Madison, Wisconsin.
Sergey TarimaDivision of Biostatistics, Institute of Health and Equity, Medical College of Wisconsin, Milwaukee, Wisconsin.
Joseph CarrollOphthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin.
Medical College of Wisconsin · USMarshfield Clinic · USUniversity of Wisconsin–Madison · US

Funding

Clinical and Translational Science AwardUL1TR001436 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI FREED, JULIE K · 2015 to 2025
$47.5M
Assessing Photoreceptor Structure and Function in Normal and Diseased RetinaeR01EY017607 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI Joseph Carroll · 2008 to 2026
$8.3M
Medical Scientist Training ProgramT32GM080202 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, SALZMAN, NITA H · 2010 to 2024
$5.7M
Rresearch Training Program in Vision ScienceT32EY014537 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI Elena V Semina · 2002 to 2026
$4.2M
Retinal Versus Cortical Contributions to Vision Loss in AlbinismR01EY024969 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI CARROLL, JOSEPH, DEYOE, EDGAR A · 2015 to 2018
$2.0M
VISION RES LAB: HERPETIC KERATIC, CORE PIGMENT GENES, RETINITIS PIGMENTOSAC06RR016511 · NCRR · MEDICAL COLLEGE OF WISCONSIN · PI DUNN, MICHAEL J · 2002 to 2002
$1.4M
NCATS NIH HHS UL1 TR001436NCRR NIH HHS C06 RR016511NEI NIH HHS R01 EY017607NEI NIH HHS R01 EY024969NEI NIH HHS T32 EY014537NIGMS NIH HHS T32 GM080202
6 · The paper itself

Abstract

Purpose: To assess the impact of two Design: Prospective, cross-sectional study. Participants: A total of 164 participants with normal vision (67 male and 97 female; mean ± standard deviation [SD] age = 30.5 ± 12.8 years) were recruited. Methods: Sequencing of more than 100 pigmentation-related genes was performed, and results were reviewed for the presence or absence of the Main Outcome Measures: Foveal pit depth, diameter, volume, and FAZ area in relation to the presence of hypomorphic alleles R402Q and S192Y on the Results: Heterozygosity for the Conclusions: Although the role of the

Indexed as

FAZ, foveal avascular zoneFoveal avascular zoneFoveal developmentFoveal morphologyGeneticsPigmentationRetinaRetinal imagingSD, standard deviation

Identifiers

PMID36246950
PMCPMC9560529
OpenAlexW3213342015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.