Evidence map›Paper›PMID 36246922›Full record

ArticleFrontiers in endocrinology2022

Mechanism of negative modulation of FSH signaling by salt-inducible kinases in rat granulosa cells.

Marah Armouti, Miriam Rodriguez-Esquivel, Carlos Stocco

Abstract read
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Marah ArmoutiDepartment of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL, United States.
Miriam Rodriguez-EsquivelDepartment of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL, United States.
Carlos StoccoDepartment of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL, United States.

Funding

Salt-Inducible Kinase Regulation of Ovarian Granulosa CellsR01HD097202 · NICHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI STOCCO, CARLOS OSCAR · 2019 to 2023
$1.7M
NICHD NIH HHS R01 HD097202
6 · The paper itself

Abstract

The optimal development of preovulatory follicles needs follicle-stimulating hormone (FSH). Recent findings revealed that salt-inducible kinases (SIKs) inhibit FSH actions in humans and rodents. This report seeks to increase our understanding of the molecular mechanisms controlled by SIKs that participate in the inhibition of FSH actions in primary rat granulosa cells (GCs). The results showed that FSH causes a transient induction of

Indexed as

Proto-Oncogene Proteins c-aktReceptors, FSHAnimalsColforsinCyclic AMP-Dependent Protein KinasesCyclic AMP Response Element-Binding ProteinFemaleFollicle Stimulating HormoneGranulosa CellsHumansProtein Serine-Threonine KinasesRatsRNA, MessengerSignal TransductionColforsinCyclic AMP-Dependent Protein KinasesCyclic AMP Response Element-Binding ProteinFollicle Stimulating HormoneProtein Serine-Threonine KinasesProto-Oncogene Proteins c-aktReceptors, FSHRNA, MessengerSik1 protein, ratCREBCRTC2granulosa cellsovarySIKssteroidogenesis

Identifiers

PMID36246922
PMCPMC9556844

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.