ArticleFrontiers in endocrinology2022
Renal fat fraction is significantly associated with the risk of chronic kidney disease in patients with type 2 diabetes.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 19 citations in OpenAlex.
- Review
- Multimodal Magnetic Resonance Imaging in Diabetic Kidney Disease: From Pathophysiological Insights to Clinical Applications.Diagnostics (Basel, Switzerland) · 2026Review
- Renal fat fraction quantified by MRI-Dixon predicts the renal function progression in patients with type 2 diabetes mellitus: a prospective cohort study.Journal of endocrinological investigation · 2026Article
- Association Between Renal Fat Fraction and Early Biomarkers of Kidney Injury in Patients with Type 2 Diabetes Mellitus.Journal of clinical medicine · 2026Article
- A comparison study to assess U-Net driven volumetric versus single-slice analysis and MRI sequences with different volume coverage to detect renal sinus fat in people with and without diabetes.Scientific reports · 2026Article
- Ectopic lipid deposition in kidney diseases: mechanisms in specific cell types and therapeutic strategies.Frontiers in endocrinology · 2026Review
- Association of hepatic steatosis with MRI-defined renal steatosis in type 2 diabetes: a cross-sectional imaging and clinical modeling study.Frontiers in nutrition · 2026Article
- Comparative effects of sevoflurane and desflurane on postoperative renal function in patients with type 2 Diabetes mellitus.Renal failure · 2025Article
- Renal Fat Accumulation Assessed by MRI or CT and Its Association with Clinical and Metabolic Disorders: A Systematic Imaging Review.Journal of clinical medicine · 2025Review
- Multiorgan Imaging for Interorgan Crosstalk in Cardiometabolic Diseases.Circulation research · 2025Review
- Renal ectopic fat deposition and hemodynamics in type 2 diabetes mellitus assessment with magnetic resonance imaging.Insights into imaging · 2025Article
- High Remnant Cholesterol is Associated with the Development of Diabetic Kidney Disease in Patients with Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Renal fat deposition measured on dixon-based MRI is significantly associated with early kidney damage in obesity.Abdominal radiology (New York) · 2024Article
- Quantitative assessment of renal steatosis in patients with type 2 diabetes mellitus using the iterative decomposition of water and fat with echo asymmetry and least squares estimation quantification sequence imaging: repeatability and clinical implications.Quantitative imaging in medicine and surgery · 2024Article
- Associations between metabolic dysfunction-associated fatty liver disease, chronic kidney disease, and abdominal obesity: a national retrospective cohort study.Scientific reports · 2024Article
- Are we ready for an adipocentric approach in people living with type 2 diabetes and chronic kidney disease?Clinical kidney journal · 2024Review
- A Predictive Nomogram for the Occurrence of Gastroesophageal Reflux Disease After Sleeve Gastrectomy: A Study Based on Preoperative HERM.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease.Nature reviews. Nephrology · 2023Review
- mDIXON-Quant for differentiation of renal damage degree in patients with chronic kidney disease.Frontiers in endocrinology · 2023Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Backgrounds: Ectopic fat deposition is closely related to chronic kidney disease (CKD). Currently, there are few population studies that have been conducted to determine the relationship between renal parenchyma fat deposition and the risk of CKD among patients with type 2 diabetes mellitus (T2DM). Therefore, we employed magnetic resonance imaging (MRI) to detect renal parenchyma fat content in individuals with T2DM, expressed as renal fat fraction (FF), to explore whether renal FF is an important risk factor for CKD in patients with T2DM. Methods: In this cross-sectional study, 189 subjects with T2DM were enrolled. CKD was defined as the estimated glomerular filtration rate (eGFR)<60 mL/min/1.73m Results: The patients were divided into three groups according to tertiles of the renal FF level (2.498 - 7.434). As renal FF increases, patients tend to be older, and more abdominally obese, with a decreased eGFR (p<0.05). After adjustment for potential confounders, patients in the highest tertile of renal FF had a significantly increased risk of CKD than those in the lowest tertile (odds ratio (OR) = 3.98, 95% confidence interval (CI) = 1.12 - 14.09, p = 0.032), and the area under the ROC curve for this model was 0.836 (0.765-0.907). Conclusions: The renal FF is significantly independently associated with CKD in patients with T2DM.
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