Evidence map›Paper›PMID 36246898›Full record

ArticleFrontiers in endocrinology2022

Obesity is associated with a higher Torque Teno viral load compared to leanness.

Carsten T Herz, Oana C Kulterer, Dorian Kulifaj, Fanny Gelas, Bernhard Franzke, Frederik Haupenthal, Gerhard Prager, Felix B Langer, Rodrig Marculescu, Alexander R Haug and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Immune Monitoring Goes Viral - Torque Teno Virus for Immunologic Risk Stratification After Kidney Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Review
  4. Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Carsten T HerzDivision of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Oana C KultererDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Dorian KulifajR&D Molecular Diagnostics, bioMérieux Société Anonyme (SA), Verniolle, France.
Fanny GelasR&D Molecular Diagnostics, bioMérieux Société Anonyme (SA), Verniolle, France.
Bernhard FranzkeResearch Platform Active Ageing, Department of Nutritional Sciences, University of Vienna, Vienna, Austria.
Frederik HaupenthalDivision of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Gerhard PragerDivision of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria.
Felix B LangerDivision of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria.
Rodrig MarculescuDivision of Medical-Chemical Laboratory Diagnostics, Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Alexander R HaugDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Florian W KieferDivision of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Gregor BondDivision of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Medical University of Vienna · ATbioMérieux (France) · FRUniversity of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Obesity affects a rising proportion of the population and is an important risk factor for unfavorable outcomes in viral disease including severe acute respiratory syndrome coronavirus 2- associated diseases. Torque Teno virus (TTV) is a ubiquitous and apathogenic virus which reflects the immune function of its host. The aim of this study was to investigate the association between obesity and TTV load - an indirect marker of compromised viral immune response. Methods: TTV was quantified by TTV R-GENE Results: TTV load was higher in individuals with obesity (median 2.39, IQR: 1.69-3.33 vs. 1.88, IQR 1.08-2.43 log10 copies/mL; Discussion: A higher TTV load in obese individuals may reflect compromised immune function and thus might serve for risk stratification of unfavorable outcomes during infectious disease, including coronavirus disease 2019, in this population. Our data warrant further analysis of TTV-based risk assessment in obese individuals in the context of infectious disease-associated outcomes.

Indexed as

COVID-19DNA Virus InfectionsTorque teno virusHumansInterleukin-6ObesityThinnessVitamin DInterleukin-6Vitamin Dbariatric surgeryimmunocompetenceobesitytorque teno virusweight loss

Identifiers

PMID36246898
PMCPMC9554490
OpenAlexW4297545810

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.