ArticleNature cardiovascular research2022
Smad3 regulates smooth muscle cell fate and mediates adverse remodeling and calcification of the atherosclerotic plaque.
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In one paragraph
Article in Nature cardiovascular research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 5% of its field
What it found
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Comprehensive Integration of Multiple Single-Cell Transcriptomic Data Sets Defines Distinct Cell Populations and Their Phenotypic Changes in Murine Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2024Pooled it
- Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis.Cell reports · 2023Pooled it
- Protein-protein interaction network architecture of human polygenic traits reveals domain-spanning connectivity and evolutionary pressures.Genome biology · 2026Article
- Inflammation in atherosclerosis: Drivers, mechanisms and therapies.Acta pharmaceutica Sinica. B · 2026Review
- The nonexcitable smooth muscle: remodeling the smooth muscle ion transport toolkit in disease.Physiological reviews · 2026Review
- Smooth Muscle Cell Cytoglobin is a Negative Regulator of Atherosclerotic Fibrous Cap Development.bioRxiv : the preprint server for biology · 2026Article
- Atherosclerosis Profiling Reveals BHLHE40 as a Candidate Modulator of VSMC.Circulation research · 2026Article
- Vascularized Cardiac Tissue Engineering: From Advances in Biofabrication to Translational Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Vascular smooth muscle cell state trajectories mediate molecular mechanisms of coronary disease risk.Nature communications · 2026Article
- Monocytes Defined by Platelet Interactions and Oxidative Stress Signaling Underlie HIV-Associated Atherosclerosis.Journal of the American Heart Association · 2026Article
- Endothelial to mesenchymal transition in cardiovascular diseases: molecular insights and clinical perspectives.European heart journal · 2026Review
- HDL Regulates TGFβ-Receptor Lipid Raft Partitioning, Restoring Contractile Features of Cholesterol-Loaded Vascular Smooth Muscle Cells.JACC. Basic to translational science · 2026Article
- Integrative functional genomics analysis identifies pleiotropic genes for vascular diseases.Nature communications · 2026Article
- Risk of Cardiovascular Disease Mortality in Patients With Diagnosed Cancer and Associated Genetic and Proteomic Mechanisms: A UK Biobank-Based Cohort Study.Journal of the American Heart Association · 2026Article
- A cell and transcriptome atlas of human arterial vasculature.Cell genomics · 2025Article
- Review
- Plasminogen activator inhibitor 1 promotes aortic aging-like pathophysiology in humans and mice.The Journal of clinical investigation · 2025Article
- Mitigating inconsistencies in GWAS follow-up analyses with LocusCompare2.Nature genetics · 2025Article
- Smooth muscle expression of RNA editing enzyme ADAR1 controls activation of the RNA sensor MDA5 in atherosclerosis.Nature cardiovascular research · 2025Article
- Enhancer-targeting CRISPR screens at coronary artery disease loci suggest shared mechanisms of disease risk.medRxiv : the preprint server for health sciences · 2025Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Paul ChengDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Robert C WirkaDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Juyong Brian KimDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Hyun-Jung KimDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Trieu NguyenDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Ramendra KunduDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Quanyi ZhaoDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Disha SharmaDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Albert PedrozaDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305.
Manabu NagaoDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Dharini IyerDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Michael P FischbeinDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305.
Thomas QuertermousDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Stanford University · US
Funding
Causal variant association mechanisms in TCF21 binding coronary disease lociR01HL134817 · NHLBI · STANFORD UNIVERSITY · PI THOMAS QUERTERMOUS · 2017 to 2026
$6.2MMechanism of the Coronary Heart Disease Association at Chromosome 6q23.2R01HL109512 · NHLBI · STANFORD UNIVERSITY · PI QUERTERMOUS, THOMAS · 2011 to 2019
$6.1MThe SMAD3 signaling network in coronary artery disease riskR01HL139478 · NHLBI · STANFORD UNIVERSITY · PI THOMAS QUERTERMOUS · 2018 to 2026
$3.7MPDGFD regulates a transcriptional network to modulate smooth muscle cell transition and coronary artery disease riskR01HL156846 · NHLBI · STANFORD UNIVERSITY · PI QUERTERMOUS, THOMAS · 2021 to 2024
$2.7MIdentifying tobacco-genetic interactions through study of the aryl hydrocarbon receptor pathway.R01HL151535 · NHLBI · STANFORD UNIVERSITY · PI QUERTERMOUS, THOMAS · 2021 to 2024
$2.7MStanford Integrated Cardiovascular/Pulmonary Residency Research Training ProgramR38HL143615 · NHLBI · STANFORD UNIVERSITY · PI Michael Peter Fischbein, Marlene Rabinovitch · 2020 to 2026
$2.2MGene regulatory networks controlling smooth muscle phenotype and vasculardisease riskR01HL171045 · NHLBI · STANFORD UNIVERSITY · PI THOMAS QUERTERMOUS · 2024 to 2026
$2.1MLncRNA Transcriptional Mechanisms of Coronary Artery Disease RiskR01HL145708 · NHLBI · STANFORD UNIVERSITY · PI QUERTERMOUS, THOMAS · 2019 to 2022
$1.6MIdentification of causal coronary heart disease variation in smooth muscle cellsR33HL120757 · NHLBI · STANFORD UNIVERSITY · PI QUERTERMOUS, THOMAS · 2016 to 2018
$1.6MMarfan Aortic Embryologic Origin Influences miR-29b Regulators and TargetsR01AR066629 · NIAMS · STANFORD UNIVERSITY · PI FISCHBEIN, MICHAEL PETER · 2016 to 2020
$1.5MFrom Locus to Function: Role of ZEB2 in Human Risk of Coronary Artery DiseaseK08HL153798 · NHLBI · STANFORD UNIVERSITY · PI CHENG, PAUL PO SHENG · 2020 to 2024
$933kRegulation of Inflammation and Atherosclerosis by TCF21K08HL133375 · NHLBI · STANFORD UNIVERSITY · PI KIM, JUYONG BRIAN · 2016 to 2020
$840kNHLBI NIH HHS F32 HL143847NHLBI NIH HHS F32 HL154681NHLBI NIH HHS K08 HL133375NHLBI NIH HHS K08 HL152308NHLBI NIH HHS K08 HL153798NHLBI NIH HHS R01 HL109512NHLBI NIH HHS R01 HL134817NHLBI NIH HHS R01 HL139478NHLBI NIH HHS R01 HL145708NHLBI NIH HHS R01 HL151535NHLBI NIH HHS R01 HL156846NHLBI NIH HHS R01 HL171045NHLBI NIH HHS R33 HL120757NHLBI NIH HHS R38 HL143615NIAMS NIH HHS R01 AR066629
Abstract
Atherosclerotic plaques consist mostly of smooth muscle cells (SMC), and genes that influence SMC phenotype can modulate coronary artery disease (CAD) risk. Allelic variation at 15q22.33 has been identified by genome-wide association studies to modify the risk of CAD and is associated with the expression of
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.