ArticlePakistan journal of medical sciences
Study on the clinical correlation between the expression of serum TNF-α and iNOS as well as cognitive impairment and disease burden in patients with schizophrenia.
Article in Pakistan journal of medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.
- Processing Speed Impairment in Schizophrenia: An Updated Systematic Review and Meta-Analysis.JAMA psychiatry · 2026Pooled it
- Relationships Between Immune-Inflammatory Features and Social Cognitive Impairments in Patients With Schizophrenia Spectrum Disorders: A Systematic Review.Brain and behavior · 2025Pooled it
- Abnormalities in nitric oxide synthase system function and their association with cognitive function in first-episode schizophrenia patients.Schizophrenia (Heidelberg, Germany) · 2026Article
- Correlations of oxidative stress markers with niacin sensitivity in male patients with chronic schizophrenia.BMC psychiatry · 2025Article
- Research on the correlation of nitric oxide-induced neuronal cell pyroptosis with schizophrenia and its cognitive impairment.BMC psychiatry · 2025Article
- Effects of modifying the pulse width on cognitive side effects with electroconvulsive therapy for schizophrenia.Schizophrenia research. Cognition · 2025Article
- Association of TNF and TLR2 genes with blood parameter levels in Mexican patients with schizophrenia.BMC psychiatry · 2025Article
- Correlations of cognitive function with serum levels of homocysteine, sex hormone binding globulin, and leptin in patients with schizophrenia.Pakistan journal of medical sciences · 2024Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To investigate the clinical correlation between the expression of serum tumor necrosis factor-α (TNF-α) and inducible nitric oxide synthase (iNOS) as well as cognitive impairment and disease burden in patients with first-episode schizophrenia. Methods: A total of 102 patients with first-episode schizophrenia admitted to the Department of Psychiatry, Hainan Province Anning Hospital from June 2018 to June 2020 were randomly selected as the observation group, and 102 healthy people who underwent physical examination in our hospital during the same period were selected as the control group. Enzyme-linked immunosorbent assay (ELISA) was used to detect the expression level of serum TNF-α in each group, and the colorimetric method was adopted for detecting the expression level of serum iNOS in each group; Moreover, cognitive function of patients was assessed by MATRICS Consensus Cognitive Battery (MCCB), disease burden was assessed by Family Burden of Disease Scale (FBS), and the correlation between the expression of serum TNF-α and iNOS as well as cognitive impairment and disease burden was analyzed by Results: The serum levels of TNF-α, iNOS, trail making test scores and FBS scores of the observation group were significantly higher than those of the control group ( Conclusions: Patients with first-episode schizophrenia have remarkably increased expression levels of serum TNF-α and iNOS, which is associated with cognitive impairment and disease burden.
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