Evidence map›Paper›PMID 36246568›Full record

ArticleDisease markers2022

Analysis of Adrenocorticotropic Hormone and Cortisol Levels in Acute Respiratory Distress Syndrome COVID-19 Patients.

Ferdy Royland Marpaung, Victoria Mayasari, Hanna Sidjabat, Sidarti Soehita, Bambang Pujo Semedi, Ida Parwati, Titin Andri Wihastuti, Agustin Iskandar, Aryati

Abstract read
In one paragraph

Article in Disease markers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ferdy Royland MarpaungDepartment of Clinical Pathology Dr. Soetomo Hospital/Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.ORCID https://orcid.org/0000-0001-6570-1877
Victoria MayasariDepartment of Clinical Pathology Dr. Soetomo Hospital/Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.ORCID https://orcid.org/0000-0001-9640-527X
Hanna SidjabatMenzies Health Institute Queensland, Griffith University, Queensland, Australia.ORCID https://orcid.org/0000-0001-5625-1317
Sidarti SoehitaDepartment of Clinical Pathology Dr. Soetomo Hospital/Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Bambang Pujo SemediDepartment of Anesthesiology and Reanimation Dr. Soetomo Hospital/Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.ORCID https://orcid.org/0000-0001-8829-1540
Ida ParwatiDepartment of Clinical Pathology, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia.ORCID https://orcid.org/0000-0002-9700-589X
Titin Andri WihastutiDepartment of Biomedical Science, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.ORCID https://orcid.org/0000-0002-1419-7225
Agustin IskandarDepartment of Clinical Pathology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.ORCID https://orcid.org/0000-0001-9204-1958
AryatiDepartment of Clinical Pathology Dr. Soetomo Hospital/Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.ORCID https://orcid.org/0000-0001-9055-0177

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: SARS-CoV-2 infection may cause multiple organ failure. However, scarce information can be found on the impact on the endocrine system. This study was conducted to determine plasma Adrenocorticotropic hormone (ACTH) and plasma cortisol levels in a cohort of COVID-19 patients with Acute Respiratory Distress Syndrome (ARDS). Methods: A prospective cohort study was conducted on COVID-19 patients who manifested ARDS and were admitted to the ICU of Dr. Soetomo Tertiary Hospital, Surabaya, Indonesia. Morning plasma ACTH and plasma total cortisol were measured on 45 recruited patients. The outcome of the patient was justified based on the survivance on days 7th and 30th during the follow-up with groupings of surviving for survived patients and nonsurvive for deceased patients. Results: The ACTH and cortisol median were 1.06 (0.5-64.57) pg/mL and 17.61 (0.78-75) Conclusion: ACTH or cortisol alone has no correlation to the outcome of these patients. Therefore, further study of the potential use of corticosteroid treatments guided by ACTH and cortisol levels in reducing the risk of ARDS warrants further investigation.

Indexed as

COVID-19Respiratory Distress SyndromeAdrenal Cortex HormonesAdrenocorticotropic HormoneHumansHydrocortisoneProspective StudiesSARS-CoV-2Adrenal Cortex HormonesAdrenocorticotropic HormoneHydrocortisone

Identifiers

PMID36246568
PMCPMC9553547

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.