ArticleCurrent research in neurobiology2021
Evolution of interictal spiking during the latent period in a mouse model of mesial temporal lobe epilepsy.
Article in Current research in neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- GABAFrontiers in neural circuits · 2022Pooled it
- Article
- Preoptic area influences sleep-related seizures in a genetic epilepsy mouse model.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Ellagic acid and allopurinol decrease HExperimental brain research · 2022Article
- Hippocampal gamma and sharp-wave ripple oscillations are altered in a Cntnap2 mouse model of autism spectrum disorder.Cell reports · 2021Article
- How Can Animal Models Advance Research into High Frequency Oscillations: Guidelines for Recording, Detection and Analysis.Epilepsy currentsReview
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4 authors at 1 institution in 1 country.
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Abstract
Interictal spikes and high-frequency oscillations (HFOs, ripples: 80-200 Hz, fast ripples: 250-500 Hz) occur in epileptic patients and in animal models of mesial temporal lobe epilepsy (MTLE). In this study, we explored how type 1 and type 2 interictal spikes as well as ripples and fast ripples evolve during the latent period in the hippocampus of pilocarpine-treated mice. Depth EEG recordings were obtained from the hippocampus CA3 subfield of adult male mice (n = 5, P60-P100) starting one day before pilocarpine-induced status epilepticus up to the first spontaneous seizure, the so-called latent period. We found that rates of type 1 (n = 1 655) and type 2 (n = 2 309) interictal spikes were significantly lower during the late phase of the latent period compared to its early and mid phase (p < 0.001). However, rates of type 1 spikes associated with ripples (n = 266) or fast ripples (n = 106), as well as rates of type 2 interictal spikes associated with ripples (n = 233), were significantly higher during the late phase compared to the early and mid phases (p < 0.05). Our findings reveal that an increase of type 1 interictal spikes co-occurring with ripples or fast ripples and an increase of type 2 interictal spikes co-occurring with ripples mark the end of the latent period. We propose that changes in the occurrence of interictal spike associated with HFOs represent a biomarker of epileptogenicity in this mouse model of MTLE.
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