Evidence map›Paper›PMID 36246507›Full record

ArticleCurrent research in neurobiology2021

Therapeutic effects of TP5, a Cdk5/p25 inhibitor, in

Judith Tran, Shane K B Taylor, Anika Gupta, Niranjana Amin, Harish Pant, Bhagwati P Gupta, Ram K Mishra

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Cyclin-dependent kinase 5 (CDK5) inhibitors in Parkinson disease.Journal of cellular and molecular medicine · 2024
    Review
  4. Three decades of Cdk5.Journal of biomedical science · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Judith TranDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
Shane K B TaylorDepartment of Biology, McMaster University, Hamilton, ON, Canada.
Anika GuptaDepartment of Biology, McMaster University, Hamilton, ON, Canada.
Niranjana AminNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Harish PantNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Bhagwati P GuptaDepartment of Biology, McMaster University, Hamilton, ON, Canada.
Ram K MishraDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
McMaster University · CANational Institutes of Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's Disease (PD) is a chronic progressive neurodegenerative disease. Current treatments for PD are symptomatic and only increase striatal dopamine levels. Proactive neuroprotective approaches that slow the progression of PD and maintain appropriate dopamine neuron populations are needed to treat the disease. One suggested mechanism contributing to the pathology of PD involves the binding of cyclin-dependent kinase 5 (Cdk5) to p25, creating a hyperactivated complex to induce cell death. The objective of this study is to investigate the neuroprotective and neurorestorative properties of Truncated Peptide 5 (TP5), a derivative of the p35 activator involved in Cdk5 regulation, via the inhibition of Cdk5/p25 complex function.

Indexed as

Caenorhabditis elegansCdk5/p25Dopaminergic neuronsParaquatParkinson’s diseaseSH-SY5Y cellsTP5

Identifiers

PMID36246507
PMCPMC9559888
OpenAlexW3136807904

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.