Evidence map›Paper›PMID 36246504›Full record

ArticleCurrent research in neurobiology2021

Anterior thalamic nuclei neurons sustain memory.

S C Barnett, L C Parr-Brownlie, B A L Perry, C K Young, H E Wicky, S M Hughes, N McNaughton, J C Dalrymple-Alford

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
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  11. Anterior thalamic circuits crucial for working memory.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

S C BarnettSchool of Psychology, Speech and Hearing, University of Canterbury, Christchurch, New Zealand.
L C Parr-BrownlieBrain Research New Zealand, Co-hosted by the University of Auckland and University of Otago, New Zealand.
B A L PerrySchool of Psychology, Speech and Hearing, University of Canterbury, Christchurch, New Zealand.
C K YoungBrain Health Research Centre, University of Otago, Dunedin, New Zealand.
H E WickyBrain Research New Zealand, Co-hosted by the University of Auckland and University of Otago, New Zealand.
S M HughesBrain Research New Zealand, Co-hosted by the University of Auckland and University of Otago, New Zealand.
N McNaughtonBrain Health Research Centre, University of Otago, Dunedin, New Zealand.
J C Dalrymple-AlfordSchool of Psychology, Speech and Hearing, University of Canterbury, Christchurch, New Zealand.
University of Auckland · NZBrain Research New Zealand · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A hippocampal-diencephalic-cortical network supports memory function. The anterior thalamic nuclei (ATN) form a key anatomical hub within this system. Consistent with this, injury to the mammillary body-ATN axis is associated with examples of clinical amnesia. However, there is only limited and indirect support that the output of ATN neurons actively enhances memory. Here, in rats, we first showed that mammillothalamic tract (MTT) lesions caused a persistent impairment in spatial working memory. MTT lesions also reduced rhythmic electrical activity across the memory system. Next, we introduced 8.5 Hz optogenetic theta-burst stimulation of the ATN glutamatergic neurons. The exogenously-triggered, regular pattern of stimulation produced an acute and substantial improvement of spatial working memory in rats with MTT lesions and enhanced rhythmic electrical activity. Neither behaviour nor rhythmic activity was affected by endogenous stimulation derived from the dorsal hippocampus. Analysis of immediate early gene activity, after the rats foraged for food in an open field, showed that exogenously-triggered ATN stimulation also increased Zif268 expression across memory-related structures. These findings provide clear evidence that increased ATN neuronal activity supports memory. They suggest that ATN-focused gene therapy may be feasible to counter clinical amnesia associated with dysfunction in the mammillary body-ATN axis.

Indexed as

Anterior thalamic nucleiEpisodic memoryExtended hippocampal systemGlutamatergicImmediate early geneLesionsMammillothalamc tractOptogeneticsRecovery of functionSpatial memoryThetaWorking memory

Identifiers

PMID36246504
PMCPMC9559952
OpenAlexW3203714521

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.