Evidence map›Paper›PMID 36246177›Full record

ArticleOphthalmology science2022

Genetic Risk of Cardiovascular Disease Is Associated with Macular Ganglion Cell-Inner Plexiform Layer Thinning in an Early Glaucoma Cohort.

Henry Marshall, Sean Mullany, Xikun Han, Ella C Berry, Mark M Hassall, Ayub Qassim, Thi Nguyen, Georgina L Hollitt, Lachlan S W Knight, Bronwyn Ridge and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Henry MarshallDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, Australia.
Sean MullanyDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, Australia.
Xikun HanStatistical Genetics Laboratory, QIMR Berghofer Medical Research Institute, Herston, Brisbane, Australia.
Ella C BerryDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, Australia.
Mark M HassallDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, Australia.
Ayub QassimDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, Australia.
Thi NguyenDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, Australia.
Georgina L HollittDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, Australia.
Lachlan S W KnightDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, Australia.
Bronwyn RidgeDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, Australia.
Joshua SchmidtDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, Australia.
Caroline CrowleyDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, Australia.
Angela SchulzFaculty of Health and Medical Sciences, Macquarie University, Sydney, Australia.
Richard A MillsDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, Australia.
Ashish AgarDepartment of Ophthalmology, University of New South Wales, Sydney, Australia.
Anna GalanopoulosDiscipline of Ophthalmology and Visual Sciences, University of Adelaide, Adelaide, Australia.
John LandersDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, Australia.
Paul R HealeyCentre for Vision Research, University of Sydney, Sydney, Australia.
Stuart L GrahamDepartment of Ophthalmology, University of New South Wales, Sydney, Australia.
Alex W HewittMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
Robert J CassonDiscipline of Ophthalmology and Visual Sciences, University of Adelaide, Adelaide, Australia.
Stuart MacGregorStatistical Genetics Laboratory, QIMR Berghofer Medical Research Institute, Herston, Brisbane, Australia.
Owen M SiggsDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, Australia.
Jamie E CraigDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To evaluate the association between genetic risk for cardiovascular disease and retinal thinning in early glaucoma. Design: Prospective, observational genetic association study. Participants: Multicohort study combining a cohort of patients with suspect and early manifest primary open-angle glaucoma (POAG), a cohort of patients with perimetric POAG, and an external normative control cohort. Methods: A cardiovascular disease genetic risk score was calculated for 828 participants from the Progression Risk of Glaucoma: Relevant SNPs [single nucleotide polymorphisms] with Significant Association (PROGRESSA) study. Participants were characterized as showing either predominantly macular ganglion cell-inner plexiform layer (GCIPL), predominantly peripapillary retinal nerve fiber layer (pRNFL) or equivalent macular GCIPL and pRNFL spectral-domain OCT thinning. The cardiovascular disease genetic risk scores for these groups were compared to an internal reference group of stable suspected glaucoma and of an external normative population. Replication was undertaken by comparing the phenotypes of participants from the Australia New Zealand Registry of Advanced Glaucoma (ANZRAG) with the normative control group. Main Outcome Measures: Spectral-domain OCT and Humphrey Visual Field (HVF) change. Results: After accounting for age, sex, and intraocular pressure (IOP), participants with predominantly macular GCIPL thinning showed a higher cardiovascular disease genetic risk score than reference participants (odds ratio [OR], 1.76/standard deviation [SD]; 95% confidence interval [CI], 1.18-2.62; Conclusions: This study highlighted the relationship between cardiovascular disease and retinal thinning in suspect and manifest glaucoma cases.

Indexed as

ANOVA, analysis of varianceANZRAG, Australia New Zealand Registry of Advanced GlaucomaCardiovascular diseaseCI, confidence intervalDDLS, Disc Damage Likelihood ScaleGCIPL, ganglion cell–inner plexiform layerGlaucomaHVF, Humphrey Visual FieldIOP, intraocular pressureMacular GCIPLOR, odds ratioParacentral visual fieldPOAG, primary open-angle glaucomapRNFL, peripapillary retinal nerve fiber layerPROGRESSA, Progression Risk of Glaucoma: Relevant SNPs with Significant AssociationRetinal thinningSNP, single nucleotide polymorphismVCDR, vertical cup-to-disc ratio

Identifiers

PMID36246177
PMCPMC9559075

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.