ArticleFrontiers in physiology2022
Left atrial appendage occlusion in ventricular assist device patients to decrease thromboembolic events: A computer simulation study.
Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 13 citations in OpenAlex.
- Virtual left atrial appendage occlusion in paroxysmal atrial fibrillation during sinus rhythm predicts variable reductions in blood stasis.The Journal of physiology · 2026Article
- A monolithic patient-specific 3D-0D model for In silico investigation of hemodynamics in patients with left ventricular assist devices.Biomechanics and modeling in mechanobiology · 2026Article
- Use of in silico research in the development of abdominal and thoracic surgical devices: a systematic review.BMJ innovations · 2025Article
- Blood flow analysis with computational fluid dynamics in the left atrium after left atrial plication: a prospective study.General thoracic and cardiovascular surgery · 2024Article
- Editorial: Computational biomechanics for ventricle-arterial dysfunction and remodeling in heart failure, Volume II.Frontiers in physiology · 2022Article
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10 authors at 4 institutions in 1 country.
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Abstract
Atrial fibrillation (AF) is a common comorbidity in left ventricular assist device (LVAD) patients and has been identified as a risk factor for thromboembolic stroke. Blood stagnation within the left atrial appendage (LAA) is considered a possible major source of thrombosis and clinical studies have shown reduced thromboembolic risk after LAA occlusion (LAAO). Therefore, this study aims to investigate the effect of LAAO on thrombosis-related parameters using patient-specific simulations. Left ventricular and left atrial geometries of an LVAD patient were obtained from computed tomography and combined with hemodynamic data with either sinus rhythm (SR) or AF generated by a lumped parameter model. In four simulations applying contractile walls, stagnation volume and blood residence times were evaluated with or without AF and with or without LAAO. Reduced atrial contraction in AF resulted in unfavorable flow dynamics within the left atrium. The average atrial velocity was lower for the AF simulation when compared to SR, resulting in a 55% increase in the atrial stagnation volume (from 4.2 to 6.5 cm
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