Evidence map›Paper›PMID 36246058›Full record

ArticleIranian journal of basic medical sciences2022

Inhibition of CCR8 attenuates Ang Ⅱ-induced vascular smooth muscle cell injury by suppressing the MAPK/NF-κB pathway.

Lisi Liao, Di Song, Bobo Shi, Ming Chen, Linghu Wu, Jinfeng Xu, Fajin Dong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian journal of basic medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lisi LiaoThe Second Clinical Medical College, Jinan University; Department of Ultrasound, The First Affiliated Hospital, Southern University of Science and Technology; Department of Ultrasound, Shenzhen People's Hospital, Shenzhen 518020, Guangdong, China.
Di SongThe Second Clinical Medical College, Jinan University; Department of Ultrasound, The First Affiliated Hospital, Southern University of Science and Technology; Department of Ultrasound, Shenzhen People's Hospital, Shenzhen 518020, Guangdong, China.
Bobo ShiThe Second Clinical Medical College, Jinan University; Department of Ultrasound, The First Affiliated Hospital, Southern University of Science and Technology; Department of Ultrasound, Shenzhen People's Hospital, Shenzhen 518020, Guangdong, China.
Ming ChenThe Second Clinical Medical College, Jinan University; Department of Ultrasound, The First Affiliated Hospital, Southern University of Science and Technology; Department of Ultrasound, Shenzhen People's Hospital, Shenzhen 518020, Guangdong, China.
Linghu WuThe Second Clinical Medical College, Jinan University; Department of Ultrasound, The First Affiliated Hospital, Southern University of Science and Technology; Department of Ultrasound, Shenzhen People's Hospital, Shenzhen 518020, Guangdong, China.
Jinfeng XuThe Second Clinical Medical College, Jinan University; Department of Ultrasound, The First Affiliated Hospital, Southern University of Science and Technology; Department of Ultrasound, Shenzhen People's Hospital, Shenzhen 518020, Guangdong, China.
Fajin DongThe Second Clinical Medical College, Jinan University; Department of Ultrasound, The First Affiliated Hospital, Southern University of Science and Technology; Department of Ultrasound, Shenzhen People's Hospital, Shenzhen 518020, Guangdong, China.
Mashhad University of Medical Sciences · IRImam Reza Hospital · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Hyperinsulinemia, secondary to insulin resistance, may lead to vascular smooth muscle cell dysfunction. In the present research, we aimed to investigate the effect of Chemokine receptor 8 (CCR8) on angiotensin II (Ang II)-induced dysfunction of vascular smooth muscle cells (VSMCs) and to explore the underlying molecular mechanism. Materials and Methods: The expression of CCR8 was analyzed in diabetics and normal people by RT-PCR and ELISA. CCK-8 assay and transwell were used to explore cell proliferation and migration, and ELISA was used to measure the content of IL-6 and TNF-α. Reactive oxygen species (ROS) kit was employed to measure ROS generation. Results: The results revealed that CCR8 was highly expressed in diabetics and Ang Ⅱ-induced VSMCs. Further studies found that interfering with the expression of CCR8 significantly reduced the production of ROS and the levels of inflammatory factors in AngⅡ-induced VSMCs. Interfering with CCR8 increased the glucose uptake induced by AngⅡ+IR. More importantly, inhibition of CCR8 alleviated Ang II-induced dysfunction of VSMCs. Inhibition of CCR8 inactivated the MAPK/NF-κB signaling pathway. Conclusion: Inhibition of CCR8 attenuates Ang II-induced VSMCs injury by inhibiting the MAPK/NF-κB pathway. CCR8 may be a new biomarker related to hypertension and insulin resistance and is a new target for the treatment of human cardiovascular diseases.

Indexed as

CCR8HypertensionInflammationInsulin resistanceMAPK/NF-κB signalingOxidative

Identifiers

PMID36246058
PMCPMC9526881
OpenAlexW4306668686

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.