Evidence map›Paper›PMID 36246006›Full record

ArticleOphthalmology science2021

Retrospective Evaluation of Somatic Alterations in Cell-Free DNA from Blood in Retinoblastoma.

David H Abramson, Diana Mandelker, Jasmine H Francis, Ira J Dunkel, A Rose Brannon, Ryma Benayed, Michael F Berger, Maria E Arcila, Marc Ladanyi, Danielle Novetsky Friedman and 8 more

Open access · goldAbstract read
In one paragraph

Article in Ophthalmology science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

  1. Digital PCR Quantification of a CirculatingInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. The trends of retinoblastoma research in the past decade.International journal of ophthalmology · 2026
    Article
  4. Blood-Based Cell-Free DNA in Ophthalmic Oncology.Translational vision science & technology · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Ophthalmology science · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

David H AbramsonDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Diana MandelkerDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Jasmine H FrancisDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Ira J DunkelDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.
A Rose BrannonDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Ryma BenayedDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Michael F BergerDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Maria E ArcilaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Marc LadanyiDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Danielle Novetsky FriedmanDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.
Gowtham JayakumaranDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Monica S DiosdadoDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Melissa A RobbinsDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Dianna Haggag-LindgrenDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Neerav ShuklaDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.
Michael WalshDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.
Prachi KothariDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.
Dana W Y TsuiDepartment of Pathology, Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Purpose: Analysis of circulating tumor DNA (ctDNA) in the plasma of patients with retinoblastoma and simulating lesions. Design: Retrospective cross-sectional study of the association of plasma ctDNA from retinoblastoma and simulating lesions with disease course. Participants: Fifty-eight Memorial Sloan Kettering Cancer Center patients with retinoblastoma comprising 68 plasma ctDNA samples and 5 with retinoblastoma-simulating lesions. Methods: The ctDNA analyzed with hybridization capture and next-generation sequencing in blood (plasma) of patients who had retinoblastoma or simulating lesions were evaluated for association with clinical course of the disease. Main Outcome Measures: Presence or absence of molecular aberrations in the Results: Conclusions: Mutations in

Indexed as

CancerCell-free DNA (cfDNA)cfDNA, cell-free DNACirculating tumor DNA (ctDNA)ctDNA, circulating tumor DNAEnucleationLiquid biopsyMetastasisMolecular profiling in retinoblastomaMosaicismMSK-ACCESS, Analysis of Circulating cfDNA to Evaluate Somatic StatusMSK-IMPACT, Integrated Mutation Profiling of Actionable Cancer TargetsRB1 mutationRetinoblastomaVAF, variant allele frequency

Identifiers

PMID36246006
PMCPMC9560572
OpenAlexW3138751192

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.