ReviewFrontiers in molecular neuroscience2022
Molecular and cellular mechanisms leading to catatonia: an integrative approach from clinical and preclinical evidence.
Review in Frontiers in molecular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- Frozen emotions, frozen bodies: a systematic review of limbic system alterations in catatonia.European archives of psychiatry and clinical neuroscience · 2026Review
- Catatonia with prominent psychosocial factors: A case report.PCN reports : psychiatry and clinical neurosciences · 2026Article
- Catatonia and elevated mortality: A population-wide cohort study with healthy, sibling, and schizophrenia spectrum controls.Psychiatry and clinical neurosciences · 2026Article
- Lorazepam-induced full resolution of catatonia and psychosis in Parkinson's disease with acromegaly: a case report.Frontiers in psychiatry · 2026Article
- Methamphetamine-withdrawal catatonia resolved with mixed amphetamine salts: a case report.Frontiers in psychiatry · 2026Article
- Recognizing Catatonia Beyond Hypokinesis: Features Linked to Underdiagnosis and Training Targets.Journal of clinical medicine · 2025Article
- Trauma-induced Catatonia in Pediatric Patients: Case Series and Literature Review.Journal of child & adolescent trauma · 2025Article
- Article
- Sodium Oxybate as a Potential New Treatment for Catatonia in Patients With Depression, Bipolar Disorder, or a Psychotic Disorder: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2025Article
- Does Dysregulation Of The Indirect Pathway Contribute To The Pathophysiology Of Catatonia Through Neurotransmitter Imbalance?Clinical neuropsychiatry · 2025Article
- First episode of catatonia followed by a psychotic episode related to chronic nitrous oxide use: A case report.Drug and alcohol review · 2025Article
- Delayed drug-induced catatonia in an adolescent girl-clinical implications: a case report.Journal of medical case reports · 2024Article
- Molecular, Pathophysiological, and Clinical Aspects of Corticosteroid-Induced Neuropsychiatric Effects: From Bench to Bedside.Biomedicines · 2024Review
- Alteration of Functional Connectivity before and after Electroconvulsive Therapy in a Single Patient with Depression and Catatonia.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024Article
- Effects of a Muscle Relaxation Technique on Catatonia Symptoms Associated With Schizophrenia: A Case Report.Cureus · 2024Article
- Catatonia.Nature reviews. Disease primers · 2024Review
- Sudden onset catatonia following tricyclic antidepressant withdrawal - A case report.Indian journal of psychiatry · 2023Article
- Catatonia-like behavior and immune activation: a crosstalk between psychopathology and pathology in schizophrenia.Annals of general psychiatry · 2023Article
- Role of Calcium Modulation in the Pathophysiology and Treatment of Alzheimer's Disease.International journal of molecular sciences · 2023Review
- Rapid symptom control in neuroleptic malignant syndrome with electroconvulsive therapy: A case report.Frontiers in psychiatry · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review aims to describe the clinical spectrum of catatonia, in order to carefully assess the involvement of astrocytes, neurons, oligodendrocytes, and microglia, and articulate the available preclinical and clinical evidence to achieve a translational understanding of the cellular and molecular mechanisms behind this disorder. Catatonia is highly common in psychiatric and acutely ill patients, with prevalence ranging from 7.6% to 38%. It is usually present in different psychiatric conditions such as mood and psychotic disorders; it is also a consequence of folate deficiency, autoimmunity, paraneoplastic disorders, and even autistic spectrum disorders. Few therapeutic options are available due to its complexity and poorly understood physiopathology. We briefly revisit the traditional treatments used in catatonia, such as antipsychotics, electroconvulsive therapy, and benzodiazepines, before assessing novel therapeutics which aim to modulate molecular pathways through different mechanisms, including NMDA antagonism and its allosteric modulation, and anti-inflammatory drugs to modulate microglia reaction and mitigate oxidative stress, such as lithium, vitamin B12, and NMDAr positive allosteric modulators.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.