ArticleEvolutionary ecology2022
Are mutations usually deleterious? A perspective on the fitness effects of mutation accumulation.
Article in Evolutionary ecology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Spontaneous mutation rate and spectrum are modulated by organismal fitness.Science advances · 2026Article
- Effects of Extreme Climatic Events on Evolutionary Processes.Global change biology · 2025Review
- Low-N Protein Activity Optimization with FolDE.ArXiv · 2025Article
- Effects of inbreeding on balancing selection: insights from Fisher's geometric model.Genetics · 2025Article
- Editing multiple genes in Physalis pubescens provides valuable lessons and implications for creating new germplasm and varieties of Physalis crops.Plant & cell physiology · 2025Article
- The adaptive state determines the impact of mutations on evolving populations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mutation bias alters the distribution of fitness effects of mutations.PLoS biology · 2025Article
- Detecting Deleterious Recessive Variants in Large Yellow Croaker Using Data from 7337 Individuals.Marine biotechnology (New York, N.Y.) · 2025Article
- Reconciling theories of dominance with the relative rates of adaptive substitution on sex chromosomes and autosomes.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Host defense alteration in Caenorhabditis elegans after evolution under ionizing radiation.BMC ecology and evolution · 2024Article
- Mutations in yeast are deleterious on average regardless of the degree of adaptation to the testing environment.Proceedings. Biological sciences · 2024Article
- Gene birth in a model of non-genic adaptation.BMC biology · 2023Article
- Mosaic Recombination Inflicted Various SARS-CoV-2 Lineages to Emerge into Novel Virus Variants: a Review Update.Indian journal of clinical biochemistry : IJCB · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
All adaptive alleles in existence today began as mutations, but a common view in ecology, evolution, and genetics is that non-neutral mutations are much more likely to be deleterious than beneficial and will be removed by purifying selection. By dramatically limiting the effectiveness of selection in experimental mutation accumulation lines, multiple studies have shown that new mutations cause a detectable reduction in mean fitness. However, a number of exceptions to this pattern have now been observed in multiple species, including in highly replicated, intensive analyses. We briefly review these cases and discuss possible explanations for the inconsistent fitness outcomes of mutation accumulation experiments. We propose that variation in the outcomes of these studies is of interest and understanding the underlying causes of these diverse results will help shed light on fundamental questions about the evolutionary role of mutations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.