Evidence map›Paper›PMID 36245510›Full record

ArticleFrontiers in nutrition2022

Jingbo Zhou, Gaoshun Xu, Xinyue Li, Huayu Tu, Haoyu Li, Hong Chang, Jie Chen, Renqiang Yu, Ce Qi, Jin Sun

Open access · goldAbstract read
In one paragraph

Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Gut microbes · 2025
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Frontiers in cellular and infection microbiology · 2023
    Review
  10. Frontiers in immunology · 2023
    Review
  11. Maternal supplementation withFrontiers in microbiology · 2023
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jingbo ZhouInstitute of Nutrition and Health, Qingdao University, Qingdao, China.
Gaoshun XuInstitute of Nutrition and Health, Qingdao University, Qingdao, China.
Xinyue LiInstitute of Nutrition and Health, Qingdao University, Qingdao, China.
Huayu TuInstitute of Nutrition and Health, Qingdao University, Qingdao, China.
Haoyu LiInstitute of Nutrition and Health, Qingdao University, Qingdao, China.
Hong ChangDepartment of Pediatric Cardiology Nephrology and Rheumatism, The Affiliated Hospital of Qingdao University Medical College, Qingdao, China.
Jie ChenDepartment of Pediatric Cardiology Nephrology and Rheumatism, The Affiliated Hospital of Qingdao University Medical College, Qingdao, China.
Renqiang YuDepartment of Neonatology, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi, China.
Ce QiInstitute of Nutrition and Health, Qingdao University, Qingdao, China.
Jin SunInstitute of Nutrition and Health, Qingdao University, Qingdao, China.
Qingdao University · CNAffiliated Hospital of Qingdao University · CNNanjing Maternity and Child Health Care Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Methods: In intervention mode I, FN041 was supplemented to dams during the late trimester and lactation and pups after weaning; in intervention mode II, FN041 was supplemented after pups were weaned. AD was induced in pups with MC903 plus ovalbumin on the ear after weaning. Results: The effect of intervention mode I in preventing AD was significantly better than that of intervention mode II. Compared with the model group, the inflammatory response of the pup's ears, the proportion of spleen regulatory T cells and the plasma IgE were significantly decreased in mice in intervention mode I. Furthermore, the intestinal mucosal barrier was enhanced, and the Shannon index of the ileal microbiota was significantly increased. The microbiota structure deviated from the AD controls and shifted toward the healthy controls according to the PCoA of unweighted UniFrac. The relative abundances of Conclusion: Prenatal and postnatal administration of FN041 is an effective way to prevent AD in offspring, and its mechanism is related to remodeling of ileal microbiota and PPs immune response.

Indexed as

atopic dermatitisileal mucosal barrierLimosilactobacillus reuteriPeyer’s patchesregulatory T cellsretinol metabolismvertical transmission

Identifiers

PMID36245510
PMCPMC9554658
OpenAlexW4297549210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.