ArticleJournal of clinical epidemiology2022
Inclusion of nonrandomized studies of interventions in systematic reviews of interventions: updated guidance from the Agency for Health Care Research and Quality Effective Health Care program.
Article in Journal of clinical epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Including randomized and non-randomized studies of interventions in evidence synthesis for harms: a meta-epidemiological study.BMC medicine · 2026Pooled it
- Human papillomavirus (HPV) vaccination in women with conisation.The Cochrane database of systematic reviews · 2025Pooled it
- Pooled it
- The addition of a lateral extra-articular procedure to a primary anterior cruciate ligament reconstruction is associated with an increased rate of further surgery for cyclops lesions and restricted range of motion.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- A Systematic Review of Peer-Reviewed Studies on Preventing Sport-Related Concussion (SRC) in Adult Football (Soccer): Mapping Sparce Evidence of Rule Changes and Head-Neck Training.Healthcare (Basel, Switzerland) · 2026Review
- Effectiveness, immunogenicity and safety of human papillomavirus vaccination in non-HIV immunocompromised individuals: a systematic review.EClinicalMedicine · 2026Article
- Metformin for asthma exacerbations.The Cochrane database of systematic reviews · 2026Article
- Psychological readiness mediates performance transfer in constraints-led, game-based basketball training: evidence from a quasi-experimental study.Frontiers in psychology · 2026Article
- Article
- Effectiveness and safety of nurse-led early cognitive and sensory rehabilitation in patients with severe traumatic brain injury: a systematic review protocol.Frontiers in neurology · 2025Article
- Quality Assessment of Cohort Studies in Complementary and Alternative Medicine: A Scoping Review Over Two Decades.Iranian journal of public health · 2025Review
- Venous thromboembolism prophylaxis in adults with acute traumatic brain injury: a systematic review.Trauma surgery & acute care open · 2025Article
- Oncoming Revolution in the Next Generation of Cohort Studies.Iranian journal of public health · 2024Article
- The reporting quality of meta-epidemiological studies needs substantial improvement: a research on research study.Systematic reviews · 2024Article
- Integrating randomized controlled trials and non-randomized studies of interventions to assess the effect of rare events: a Bayesian re-analysis of two meta-analyses.BMC medical research methodology · 2024Article
- Impact of Cognitive Behavior Therapy on Sexual Dysfunction of Women in Reproductive Age: A Systematic Review.International journal of sexual health : official journal of the World Association for Sexual Health · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe developed guidance to inform decisions regarding the inclusion of nonrandomized studies of interventions (NRSIs) in systematic reviews (SRs) of the effects of interventions. STUDY DESIGN AND
settingThe guidance workgroup comprised SR experts and used an informal consensus generation method.
resultsInstead of recommending NRSI inclusion only if randomized controlled trials (RCTs) are insufficient to address the SR key question, different topics may require different decisions regarding NRSI inclusion. We identified important considerations to inform such decisions from topic refinement through protocol development. During topic scoping and refinement, considerations were related to the clinical decisional dilemma, adequacy of RCTs to address the key questions, risk of bias in NRSIs, and the extent to which NRSIs are likely to complement RCTs. When NRSIs are included, during SR team formation, familiarity with topic-specific data sources and advanced analytic methods for NRSIs should be considered. During protocol development, the decision regarding NRSI inclusion or exclusion should be justified, and potential implications explained. When NRSIs are included, the protocol should describe the processes for synthesizing evidence from RCTs and NRSIs and determining the overall strength of evidence.
conclusionWe identified specific considerations for decisions regarding NRSI inclusion in SRs and highlight the importance of flexibility and transparency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.