ArticleBiological psychiatry2023
Sex-Specific Genetic and Transcriptomic Liability to Neuroticism.
Article in Biological psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Towards scalable biomarker discovery in posttraumatic stress disorder: triangulating genomic and phenotypic evidence from a health system biobank.Molecular psychiatry · 2026Article
- Genome-wide association study of delay discounting identifies 11 loci and reveals transdiagnostic associations across mental and physical health.Molecular psychiatry · 2026Article
- Functional gradient variations in different neuroticism levels and its correlation with cell type-specific transcriptional signatures.Social cognitive and affective neuroscience · 2026Article
- Sex-specific impact of vitamin D and B9 concentrations on neuroticism: a polygenic score-based study.Frontiers in psychiatry · 2026Article
- Sex differences in personality dysfunction in help-seeking adolescents.Borderline personality disorder and emotion dysregulation · 2025Article
- Distinct explanations underlie gene-environment interactions in the UK Biobank.American journal of human genetics · 2025Article
- Relationship between personality traits and spontaneous coronary artery dissection risk: evidence from Mendelian randomization.Frontiers in cardiovascular medicine · 2025Article
- Implementation of the Methyl-Seq platform to identify tissue- and sex-specific DNA methylation differences in the rat epigenome.Epigenetics · 2024Article
- Gene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study.Nature genetics · 2024Article
- Distinct explanations underlie gene-environment interactions in the UK Biobank.medRxiv : the preprint server for health sciences · 2024Article
- Is There a Natural, Non-addictive, and Non-anti-reward, Safe, Gene-based Solution to Treat Reward Deficiency Syndrome? KB220 Variants vs GLP-1 Analogs.Journal of addiction psychiatry · 2024Article
- Leveraging sex-genetic interactions to understand brain disorders: recent advances and current gaps.Brain communications · 2024Review
- Association between suicidal ideation and tandem repeats inFrontiers in psychiatry · 2023Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundThe presentation, etiology, and relative risk of psychiatric disorders are strongly influenced by biological sex. Neuroticism is a transdiagnostic feature of psychiatric disorders displaying prominent sex differences. We performed genome-wide association studies of neuroticism separately in males and females to identify sex-specific genetic and transcriptomic profiles.
methodsNeuroticism scores were derived from the Eysenck Personality Inventory Neuroticism scale. Genome-wide association studies were performed in 145,669 females and 129,229 males from the UK Biobank considering autosomal and X chromosomal variation. Two-sided z tests were used to test for sex-specific effects of discovered loci, genetic correlates (n = 673 traits), tissue and gene transcriptomic profiles, and polygenic associations across health outcomes in the Vanderbilt University Biobank (39,692 females and 31,268 males).
resultsThe single nucleotide polymorphism heritability of neuroticism was not statistically different between males (h
conclusionsThrough a comprehensive assessment of genetic risk for neuroticism and the associated biological processes, this study identified several molecular pathways that can partially explain the known sex differences in neurotic symptoms and their psychiatric comorbidities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.