Evidence map›Paper›PMID 36244636›Full record

ArticleNeuroscience2022

Further Studies on the Role of BTBD9 in the Cerebellum, Sleep-like Behaviors and the Restless Legs Syndrome.

Shangru Lyu, Hong Xing, Yuning Liu, Pallavi Girdhar, Fumiaki Yokoi, Yuqing Li

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Sex-specific alterations of Purkinje cell firing inDystonia (Lausanne, Switzerland) · 2025
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Shangru LyuNorman Fixel Institute for Neurological Diseases, Department of Neurology, College of Medicine, University of Florida, Gainesville, FL, USA.
Hong XingNorman Fixel Institute for Neurological Diseases, Department of Neurology, College of Medicine, University of Florida, Gainesville, FL, USA.
Yuning LiuNorman Fixel Institute for Neurological Diseases, Department of Neurology, College of Medicine, University of Florida, Gainesville, FL, USA.
Pallavi GirdharNorman Fixel Institute for Neurological Diseases, Department of Neurology, College of Medicine, University of Florida, Gainesville, FL, USA.
Fumiaki YokoiNorman Fixel Institute for Neurological Diseases, Department of Neurology, College of Medicine, University of Florida, Gainesville, FL, USA.
Yuqing LiNorman Fixel Institute for Neurological Diseases, Department of Neurology, College of Medicine, University of Florida, Gainesville, FL, USA. Electronic address: yuqingli@ufl.edu.
University of Florida · US

Funding

Restless Legs Syndrome: Pathophysiology using Btbd9 Conditional Knockout MiceR01NS082244 · NINDS · UNIVERSITY OF FLORIDA · PI LI, YUQING · 2014 to 2018
$1.6M
Characterization of Meis1 mutant mice and implications in restless legs syndrome and other sleep disordersR21NS111498 · NINDS · UNIVERSITY OF FLORIDA · PI LI, YUQING · 2020 to 2021
$419k
Characterization of the involvement of the cerebellum in animal models of C9orf72 ALS/FTDR21NS118397 · NINDS · UNIVERSITY OF FLORIDA · PI LI, YUQING · 2020 to 2020
$419k
Pathophysiology and Animal Model of Restless Legs Syndrome (RLS): Btbd9 Null MicR21NS065273 · NINDS · UNIVERSITY OF FLORIDA · PI LI, YUQING · 2009 to 2010
$401k
NINDS NIH HHS R01 NS082244NINDS NIH HHS R21 NS065273NINDS NIH HHS R21 NS111498NINDS NIH HHS R21 NS118397
6 · The paper itself

Abstract

Genetic analyses have linked BTBD9 to restless legs syndrome (RLS) and sleep regulation. Btbd9 knockout mice show RLS-like motor restlessness. Previously, we found hyperactivity of cerebellar Purkinje cells (PCs) in Btbd9 knockout mice, which may contribute to the motor restlessness observed. However, underlying mechanisms for PC hyperactivity in Btbd9 knockout mice are unknown. Here, we used dissociated PC recording, brain slice recording and western blot to address this question. Our dissociated recording shows that knockout PCs had increased TEA-sensitive, Ca

Indexed as

Restless Legs SyndromeAnimalsCerebellumMiceMice, KnockoutNerve Tissue ProteinsPsychomotor Agitationras GTPase-Activating ProteinsSleepBtbd9 protein, mouseNerve Tissue Proteinsras GTPase-Activating ProteinsSyngap1 protein, mouseBK channelsBtbd9cerebellar Purkinje cellsrestless legs syndromeSK channelsSYNGAP1

Identifiers

PMID36244636
PMCPMC10367443
OpenAlexW4306168904

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.