Evidence map›Paper›PMID 36244323›Full record

ArticleBioorganic chemistry2022

SAR study on Novel truxillic acid monoester-Based inhibitors of fatty acid binding proteins as Next-Generation antinociceptive agents.

Hehe Wang, Adam Taouil, Monaf Awwa, Timothy Clement, Chuanzhou Zhu, Jinwoo Kim, Dominick Rendina, Kalani Jayanetti, Atri Maharaj, Liqun Wang and 4 more

Open access · greenAbstract read
In one paragraph

Article in Bioorganic chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Evaluating FABP5 as a Therapeutic Target for Pain Management.European journal of pain (London, England) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Hehe WangDepartment of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, United States.
Adam TaouilDepartment of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, United States.
Monaf AwwaDepartment of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, United States.
Timothy ClementDepartment of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, United States.
Chuanzhou ZhuDepartment of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, United States.
Jinwoo KimDepartment of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, United States.
Dominick RendinaDepartment of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, United States.
Kalani JayanettiDepartment of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, United States.
Atri MaharajDepartment of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, United States.
Liqun WangDepartment of Anesthesiology, Stony Brook University, Stony Brook, NY 11794-8480, United States.
Diane BogdanDepartment of Anesthesiology, Stony Brook University, Stony Brook, NY 11794-8480, United States.
Antonella PepeDepartment of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, United States.
Martin KaczochaDepartment of Anesthesiology, Stony Brook University, Stony Brook, NY 11794-8480, United States; Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, NY 11794-3400, United States.
Iwao OjimaDepartment of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, United States; Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, NY 11794-3400, United States. Electronic address: iwao.ojima@stonybrook.edu.
Stony Brook University · US

Funding

Development of the Next Generation of FABP5 Inhibitors to Treat Prostate CancerR01CA237154 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI KACZOCHA, MARTIN, OJIMA, IWAO · 2020 to 2024
$3.3M
FABPs: Novel Roles in Pain and InflammationR01DA035949 · NIDA · STATE UNIVERSITY NEW YORK STONY BROOK · PI KACZOCHA, MARTIN · 2014 to 2022
$3.0M
Metastasis of PTEN Mutant Prostate CancerR01CA275128 · NCI · COLD SPRING HARBOR LABORATORY · PI TROTMAN, LLOYD C · 2022 to 2025
$2.7M
Regulation of Cannabinoid Metabolism by Hepatic FABPsF31DA042545 · NIDA · STATE UNIVERSITY NEW YORK STONY BROOK · PI ELMES, MATTHEW WILLIAM · 2016 to 2017
$67k
NCI NIH HHS R01 CA237154NCI NIH HHS R01 CA275128NIDA NIH HHS F31 DA042545NIDA NIH HHS R01 DA035949
6 · The paper itself

Abstract

Fatty acid binding protein 5 (FABP5) is a highly promising target for the development of analgesics as its inhibition is devoid of CB

Indexed as

AnalgesicsCyclobutanesFatty Acid-Binding ProteinsBiphenyl CompoundsEstersMolecular Docking SimulationStructure-Activity RelationshipAnalgesicsbiphenylBiphenyl CompoundsCyclobutanesEstersFABP5 protein, humanFatty Acid-Binding Proteinstruxillic acidAntinociceptive agentComputer-aided drug designFABP inhibitorFatty acid binding proteinMolecular dockingSARTruxillic acid

Identifiers

PMID36244323
PMCPMC11323223
OpenAlexW4298150038

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.