Evidence map›Paper›PMID 36243875›Full record

ArticleNature communications2022

Structural basis for recognition of antihistamine drug by human histamine receptor.

Xueqian Peng, Linlin Yang, Zixuan Liu, Siyi Lou, Shiliu Mei, Meiling Li, Zhong Chen, Haitao Zhang

Abstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Virtual Screening, Synthesis and In Vitro Characterization of Histamine HInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Activity-restoring mutations in the histamine HProtein science : a publication of the Protein Society · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. GRespiratory research · 2024
    Review
  19. AR71, Histamine HInternational journal of molecular sciences · 2024
    Article
  20. Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xueqian PengHangzhou Institute of Innovative Medicine, Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, Zhejiang, China.ORCID 0000-0003-1701-2924
Linlin YangDepartment of Pharmacology, School of Basic Medical Sciences, Zhengzhou University, 450052, Zhengzhou, Henan, China.
Zixuan LiuHangzhou Institute of Innovative Medicine, Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, Zhejiang, China.ORCID 0000-0001-5690-4808
Siyi LouHangzhou Institute of Innovative Medicine, Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, Zhejiang, China.ORCID 0000-0002-3481-4905
Shiliu MeiHangzhou Institute of Innovative Medicine, Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, Zhejiang, China.
Meiling LiDepartment of Pharmacology, School of Basic Medical Sciences, Zhengzhou University, 450052, Zhengzhou, Henan, China.
Zhong ChenKey Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, 310053, Hangzhou, Zhejiang, China.ORCID 0000-0003-4755-9357
Haitao ZhangHangzhou Institute of Innovative Medicine, Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, Zhejiang, China. haitaozhang@zju.edu.cn.ORCID 0000-0003-4879-2951

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The histamine receptors belong to the G protein-coupled receptor (GPCR) superfamily, and play important roles in the regulation of histamine and other neurotransmitters in the central nervous system, as potential targets for the treatment of neurologic and psychiatric disorders. Here we report the crystal structure of human histamine receptor H

Indexed as

HistamineReceptors, HistamineHistamine AntagonistsHumansLigandsMolecular Docking SimulationReceptors, G-Protein-CoupledHistamineHistamine AntagonistsLigandsReceptors, G-Protein-CoupledReceptors, Histamine

Identifiers

PMID36243875
PMCPMC9569329

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.