Evidence map›Paper›PMID 36243844›Full record

ArticleCurrent topics in microbiology and immunology2022

AKT Isoforms in Macrophage Activation, Polarization, and Survival.

Ioanna Lapi, Maria G Daskalaki, Konstantinos Axarlis, Eleni Paflioti, Philip N Tsichlis, Eleni Vergadi, Christos Tsatsanis

Abstract read
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In one paragraph

Article in Current topics in microbiology and immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ioanna LapiLaboratory of Clinical Chemistry, School of Medicine, University of Crete, 2208, 71003, Heraklion, Crete, Greece.
Maria G DaskalakiLaboratory of Clinical Chemistry, School of Medicine, University of Crete, 2208, 71003, Heraklion, Crete, Greece.
Konstantinos AxarlisLaboratory of Clinical Chemistry, School of Medicine, University of Crete, 2208, 71003, Heraklion, Crete, Greece.
Eleni PafliotiLaboratory of Clinical Chemistry, School of Medicine, University of Crete, 2208, 71003, Heraklion, Crete, Greece.
Philip N TsichlisDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, 43210, USA.
Eleni VergadiDepartment of Pediatrics, School of Medicine, University of Crete, 70013, Heraklion, Crete, Greece.
Christos TsatsanisLaboratory of Clinical Chemistry, School of Medicine, University of Crete, 2208, 71003, Heraklion, Crete, Greece. tsatsani@med.uoc.gr.
FORTH Institute of Molecular Biology and Biotechnology · GRUniversity of Crete · GRThe Ohio State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophages display an array of activation phenotypes depending on the activation signal and the cellular microenvironment. The type and magnitude of the response depend on signaling molecules as well as on the epigenetic and metabolic status of the cells at the time of activation. The AKT family of kinases consists of three isoforms encoded by independent genes possessing similar functions and structures. Generation of research tools such as isoform-specific gene deletion mutant mice and cells and isoform-specific antibodies has allowed us to understand the role of each kinase isoform in macrophage activation and homeostasis. This chapter discusses the current evidence on the role of AKT kinases in macrophage activation, polarization, and homeostasis, highlighting the gaps in knowledge and future challenges in the field.

Indexed as

Macrophage ActivationProto-Oncogene Proteins c-aktAnimalsMacrophagesMiceProtein IsoformsSignal TransductionProtein IsoformsProto-Oncogene Proteins c-akt

Identifiers

PMID36243844
OpenAlexW4306362020

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.