Evidence map›Paper›PMID 36243680›Full record

ArticleBMC cancer2022

A comprehensive analysis of penile cancer in the region with the highest worldwide incidence reveals new insights into the disease.

Antonio Augusto Lima Teixeira Júnior, Syomara Pereira da Costa Melo, Jaqueline Diniz Pinho, Thaís Bastos Moraes Sobrinho, Thalita Moura Silva Rocha, Denner Rodrigo Diniz Duarte, Liseana de Oliveira Barbosa, Wesliany Everton Duarte, Marta Regina de Castro Belfort, Kelly Gomes Duarte and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

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  11. Human papillomavirus (HPV) and Epstein-Barr virus (EBV) in Penile Cancer in Thailand.Asian Pacific journal of cancer prevention : APJCP · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 1 country.

Antonio Augusto Lima Teixeira JúniorDepartment of Genetics and Postgraduate Program in Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Syomara Pereira da Costa MeloLaboratory of Immunofluorescence and Electron Microscopy, University Hospital of the Federal University of Maranhão, São Luís, Brazil.
Jaqueline Diniz PinhoHigher Education Center of Zé Doca, State University of Maranhão, Zé Doca, Brazil.
Thaís Bastos Moraes SobrinhoLaboratory of Immunofluorescence and Electron Microscopy, University Hospital of the Federal University of Maranhão, São Luís, Brazil.
Thalita Moura Silva RochaPostgraduate Program in Adult Health, Federal University of Maranhão, São Luís, Brazil.
Denner Rodrigo Diniz DuarteLaboratory of Immunofluorescence and Electron Microscopy, University Hospital of the Federal University of Maranhão, São Luís, Brazil.
Liseana de Oliveira BarbosaLaboratory of Immunofluorescence and Electron Microscopy, University Hospital of the Federal University of Maranhão, São Luís, Brazil.
Wesliany Everton DuartePostgraduate Program in Adult Health, Federal University of Maranhão, São Luís, Brazil.
Marta Regina de Castro BelfortLaboratory of Immunofluorescence and Electron Microscopy, University Hospital of the Federal University of Maranhão, São Luís, Brazil.
Kelly Gomes DuartePostgraduate Program in Clinical Surgery, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Antonio Lima da Silva NetoLaboratory of Immunofluorescence and Electron Microscopy, University Hospital of the Federal University of Maranhão, São Luís, Brazil.
José de Ribamar Rodrigues CalixtoUniversity Hospital of the Federal University of Maranhão, São Luís, Brazil.
Lúcio Cristiano Paiva PaivaLaboratory of Immunofluorescence and Electron Microscopy, University Hospital of the Federal University of Maranhão, São Luís, Brazil.
Francisco Sérgio Moura Silva do NascimentoUniversity Hospital of the Federal University of Maranhão, São Luís, Brazil.
Antonio Machado Alencar JuniorPostgraduate Program in Health Science, Federal University of Maranhão, São Luís, Brazil.
André Salim KhayatOncology Research Center, Federal University of Pará, Belém, Brazil.
Rita da Graça Carvalhal Frazão CorrêaUniversity Hospital of the Federal University of Maranhão, São Luís, Brazil.
Joyce Santos LagesUniversity Hospital of the Federal University of Maranhão, São Luís, Brazil.
Rodolfo Borges Dos ReisPostgraduate Program in Clinical Surgery, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Wilson Silva AraújoDepartment of Genetics and Postgraduate Program in Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Gyl Eanes Barros SilvaPostgraduate Program in Adult Health, Federal University of Maranhão, São Luís, Brazil. gyl.silva@ufma.br.
Universidade Federal do Maranhão · BRUniversidade de São Paulo · BRUniversidade Estadual do Maranhão · BRUniversidade Federal do Pará · BR

Funding

Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão 01339/17 and 01184/19
6 · The paper itself

Abstract

backgroundAlthough penile cancer (PC) is uncommon in developed countries, it is widespread in developing countries. The state of Maranhão (Northeast, Brazil) has the highest global incidence recorded for PC, and, despite its socioeconomic vulnerability, it has been attributed to human papillomavirus (HPV) infection. This study aimed to determine the histopathological features, the prevalence of HPV infection, and the immunohistochemical profile of PC in Maranhão.

methodsA retrospective cohort of 200 PC cases were evaluated. HPV detection was performed using nested-PCR followed by direct sequencing for genotyping. Immunohistochemistry (IHC) was performed using monoclonal antibodies anti-p16

resultsOur data revealed a delay of 17 months in diagnosis, a high rate of penile amputation (96.5%), and HPV infection (80.5%) in patients from Maranhão (Molecular detection). We demonstrated the high rate of HPV in PC also by histopathological and IHC analysis. Most patients presented koilocytosis (75.5%), which was associated with those reporting more than 10 different sexual partners during their lifetime (p = 0.001). IHC revealed frequent p16

conclusionsOur data reaffirmed the high incidence of HPV infection in PC cases from Maranhão and offer new insights into potential factors that may contribute to the high PC incidence in the region. We highlighted the possible association of HPV with worse clinical prognosis factors, differently from what was observed in other regions. Furthermore, our IHC analysis reinforces p16, ki-67, and p53 expression as important diagnosis and/or prognosis biomarkers, potentially used in the clinical setting in emerging countries such as Brazil.

Indexed as

Papillomavirus InfectionsPenile NeoplasmsAntibodies, MonoclonalBiomarkers, TumorCyclin-Dependent Kinase Inhibitor p16HumansIncidenceKi-67 AntigenMalePapillomaviridaePrognosisRetrospective StudiesTumor Suppressor Protein p53Antibodies, MonoclonalBiomarkers, TumorCyclin-Dependent Kinase Inhibitor p16Ki-67 AntigenTumor Suppressor Protein p53BrazilHPVKi-67Maranhãop16p53Penile cancer

Identifiers

PMID36243680
PMCPMC9569053
OpenAlexW4306292097

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.