Evidence map›Paper›PMID 36243623›Full record

ArticleHematology, transfusion and cell therapy

CAR-T cell therapy for multiple myeloma: a practical toolkit for treatment in Brazil.

Vania Hungria, Ana Alfonso Piérola, Jayr Schmidt Filho, Edvan Crusoe, Roberto José Pessoa de Magalhães Filho, Angelo Maiolino, Paula Rodríguez-Otero

Open access · diamondAbstract read
In one paragraph

Article in Hematology, transfusion and cell therapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Vania HungriaFaculdade de Ciências Médicas da Santa Casa de São Paulo (FCMSCSP), São Paulo, SP, Brazil; Clínica São Germano, São Paulo, Brazil.
Ana Alfonso PiérolaClinica Universidad de Navarra, IDISNA, Pamplona, Spain.
Jayr Schmidt FilhoA.C. Camargo Cancer Center, São Paulo, SP, Brazil.
Edvan CrusoeHospital Universitário Professor Edgar Santos da Universidade Federal da Bahia (HUPES), Salvador, BA, Brazil; Rede D'or Oncologia, Salvador, Brazil.
Roberto José Pessoa de Magalhães FilhoUniversidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
Angelo MaiolinoUniversidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil; Oncologia Américas, Rio de Janeiro, Brazil.
Paula Rodríguez-OteroClinica Universidad de Navarra, IDISNA, Pamplona, Spain. Electronic address: paurodriguez@unav.es.
Clinica Universidad de Navarra · ESUniversidade Federal do Rio de Janeiro · BRAC Camargo Hospital · BRFaculdade de Ciências Médicas da Santa Casa de São Paulo · BRUniversidade Federal da Bahia · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChimeric antigen receptor T (CAR-T) cell therapy is an emerging treatment option for relapsed/refractory multiple myeloma (RRMM) that is a multi-step process involving various stakeholders. Appropriate education on the practical logistics is therefore paramount to ensure treatment success.

methodsA group of key opinion leaders met to explore the key elements of setting up and running a CAR-T center in Brazil. For each step in the CAR-T cell therapy process, the experts agreed on basic requirements, gave their key recommendations from practical experience, and considered any remaining unanswered questions.

resultsThis paper presents best-practice recommendations and advice on how to overcome common challenges for each step in the CAR-T cell therapy process, with a focus on the current situation in Brazil. Key themes throughout the process are collaboration within the multidisciplinary team and with the referring physician, along with communication and education for patients and their caregivers.

conclusionWe believe that the expert insights presented in this paper, in particular on optimal patient selection and timing of CAR-T cell therapy, will deepen understanding of the CAR-T process and aid implementation of this novel therapy for patients with RRMM in Brazil.

Indexed as

BCMABridging therapyCAR-T cell therapyImmunotherapyMultiple myeloma

Identifiers

PMID36243623
PMCPMC10244253
OpenAlexW4297902578

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.