Evidence map›Paper›PMID 36243547›Full record

ReviewSurgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery2023

Mucosal and hormonal adaptations after Roux-en-Y gastric bypass.

Fauzi Feris, Alison McRae, Todd A Kellogg, Travis McKenzie, Omar Ghanem, Andres Acosta

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Observational
  4. Review
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fauzi FerisPrecision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Alison McRaePrecision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Todd A KelloggDivision of Endocrine and Metabolic Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota.
Travis McKenzieDivision of Endocrine and Metabolic Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota.
Omar GhanemDivision of Endocrine and Metabolic Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota.
Andres AcostaPrecision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota. Electronic address: acosta.andres@mayo.edu.

Funding

Mechanisms of Enteroendocrine L-Cell Dysfunction and Bile Adaptations to Weight LossK23DK114460 · NIDDK · MAYO CLINIC ROCHESTER · PI ACOSTA, ANDRES J · 2018 to 2022
$980k
NIDDK NIH HHS K23 DK114460
6 · The paper itself

Abstract

The aim of this study was to perform a comprehensive literature review regarding the relevant hormonal and histologic changes observed after Roux-en-Y gastric bypass (RYGB). We aimed to describe the relevant hormonal (glucagon-like peptides 1 and 2 [GLP-1 and GLP-2], peptide YY [PYY], oxyntomodulin [OXM], bile acids [BA], cholecystokinin [CCK], ghrelin, glucagon, gastric inhibitory polypeptide [GIP], and amylin) profiles, as well as the histologic (mucosal cellular) adaptations happening after patients undergo RYGB. Our review compiles the current evidence and furthers the understanding of the rationale behind the food intake regulatory adaptations occurring after RYGB surgery. We identify gaps in the literature where the potential for future investigations and therapeutics may lie. We performed a comprehensive database search without language restrictions looking for RYGB bariatric surgery outcomes in patients with pre- and postoperative blood work hormonal profiling and/or gut mucosal biopsies. We gathered the relevant study results and describe them in this review. Where human findings were lacking, we included animal model studies. The amalgamation of physiologic, metabolic, and cellular adaptations following RYGB is yet to be fully characterized. This constitutes a fundamental aspiration for enhancing and individualizing obesity therapy.

Indexed as

Gastric BypassAnimalsBlood GlucoseCholecystokininGastric Inhibitory PolypeptideGlucagon-Like Peptide 1HumansObesityPeptide YYBlood GlucoseCholecystokininGastric Inhibitory PolypeptideGlucagon-Like Peptide 1Peptide YYBariatric surgeryGastric bypassGut hormonesMetabolic adaptationsMucosal adaptationsObesityRoux-en-Y gastric bypassSatiety hormones

Identifiers

PMID36243547
PMCPMC9797451

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.