ArticleCell2022
Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection.
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Article in Cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers.
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128citing papers in PubMed
28.8field-weighted citation impact, top 1% of its field
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Who cites it
128 citing papers in PubMed, 195 citations in OpenAlex.
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68 more citing papers are in PubMed but not listed here.
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Authors and funding
25 authors at 4 institutions in 2 countries.
Daping YangDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Amanda JacobsonDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Kimberly A MeerschaertDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Joseph Joy SifakisDepartment of Chemistry, University of Chicago, Chicago, IL 60637, USA.
Meng WuDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Xi ChenDivision of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Tiandi YangDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Youlian ZhouDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Praju Vikas AnekalMicRoN Core, Harvard Medical School, Boston, MA 02115, USA.
Rachel A RuckerDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Deepika SharmaDepartment of Medicine, University of Chicago, Chicago, IL 60637, USA.
Alexandra Sontheimer-PhelpsWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
Glendon S WuDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Liwen DengDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Michael D AndersonDivision of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Samantha ChoiDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Dylan NeelDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Nicole LeeDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Dennis L KasperDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Bana JabriDepartment of Medicine, University of Chicago, Chicago, IL 60637, USA; Committee on Immunology, University of Chicago, Chicago, IL 60637, USA; Department of Pathology and Pediatrics, University of Chicago, Chicago, IL 60637, USA.
Jun R HuhDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Malin JohanssonDepartment of Medical Biochemistry, Institute of Biomedicine, University of Gothenburg, Gothenburg 40530, Sweden.
Jay R ThiagarajahDivision of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Samantha J RiesenfeldDepartment of Medicine, University of Chicago, Chicago, IL 60637, USA; Committee on Immunology, University of Chicago, Chicago, IL 60637, USA; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA; Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, USA.
Isaac M ChiuDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: isaac_chiu@hms.harvard.edu.
Harvard University · USUniversity of Chicago · USBoston Children's Hospital · USUniversity of Gothenburg · SE
Funding
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MSTRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4MULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 1990 to 2025
$29.8MCOngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepositoryRC2DK118640 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI James Richard Goldenring, Izumi Kaji · 2019 to 2026
$14.8MMedical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7MResearch Training in BiogerontologyT32AG000114 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCOTT PLETCHER · 1985 to 2026
$12.4MMAYO REHABILITATION RESEARCH TRAINING PROGRAMT32HD007447 · NICHD · MAYO CLINIC ROCHESTER · PI BASFORD, JEFFREY R. · 1993 to 2012
$3.1MDecoding Hydrogen Peroxide Signaling at Cellular Membranes (Equipment Supplement)R35GM142683 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI THIAGARAJAH, JAY · 2021 to 2025
$2.3MNociceptor neuron regulation of gastrointestinal barrier protection and host defenseR01DK127257 · NIDDK · HARVARD MEDICAL SCHOOL · PI CHIU, ISAAC MING-CHENG · 2021 to 2024
$2.2MNIA NIH HHS T32 AG000114NICHD NIH HHS T32 HD007447NIDDK NIH HHS P30 DK034854NIDDK NIH HHS P30 DK042086NIDDK NIH HHS R01 DK127257NIDDK NIH HHS RC2 DK118640NIGMS NIH HHS R35 GM142683NIGMS NIH HHS T32 GM007753NIGMS NIH HHS T32 GM144273
Abstract
Neuroepithelial crosstalk is critical for gut physiology. However, the mechanisms by which sensory neurons communicate with epithelial cells to mediate gut barrier protection at homeostasis and during inflammation are not well understood. Here, we find that Nav1.8
Indexed as
ColitisGoblet CellsAnimalsCalcitonin Gene-Related PeptideHumansMiceMucusNociceptorsReceptor Activity-Modifying Protein 1Calcitonin Gene-Related PeptideRAMP1 protein, humanRamp1 protein, mouseReceptor Activity-Modifying Protein 1CGRPcolitisgoblet cellgut barriergut-brain axismucusneuroepithelial crosstalknociceptorRamp1sensory neuron
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.