Evidence map›Paper›PMID 36242998›Full record

ArticleMed (New York, N.Y.)2022

Somatic genomic mosaicism in the brain: Identified mutations provide challenges and opportunities for the clinic.

Jerold Chun

Abstract readComment
PubMed Publisher
In one paragraph

Article in Med (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Jerold ChunSanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA, USA. Electronic address: jchun@sbpdiscovery.org.
Sanford Burnham Prebys Medical Discovery Institute · US

Funding

Altered reverse transcriptase-dependent gene diversification mechanisms in Alzheimer's disease brainsR01AG065541 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI CHUN, JEROLD · 2020 to 2024
$4.8M
Transformative research on somatic gene recombination in the normal and Alzheimer's disease-related dementia brainR01AG071465 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI CHUN, JEROLD · 2020 to 2024
$4.6M
New Down syndrome brain organization revealed by single-cell genomicsR56AG073965 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI CHUN, JEROLD · 2021 to 2022
$2.8M
NIA NIH HHS R01 AG065541NIA NIH HHS R01 AG071465NIA NIH HHS R56 AG073965
6 · The paper itself

Abstract

Recent work by Bae et al.

Indexed as

GenomicsMosaicismBrainHigh-Throughput Nucleotide SequencingHumansMutation

Identifiers

PMID36242998
OpenAlexW4306252780

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.