Evidence map›Paper›PMID 36242896›Full record

ReviewCurrent opinion in microbiology2022

Strains to go: interactions of the skin microbiome beyond its species.

Ryan Caldwell, Wei Zhou, Julia Oh

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Skin microbiome and dermatologic disorders.The Journal of clinical investigation · 2025
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ryan CaldwellThe Jackson Laboratory for Genomic Medicine, Farmington, CT, United States.
Wei ZhouThe Jackson Laboratory for Genomic Medicine, Farmington, CT, United States.
Julia OhThe Jackson Laboratory for Genomic Medicine, Farmington, CT, United States. Electronic address: julia.oh@jax.org.
Jackson Laboratory · US

Funding

Technology Development Project - Increasing the complexity of ex vivo human airway models for studying immune response to viral infectionU19AI142733 · NIAID · JACKSON LABORATORY · PI Adolfo Garcia-Sastre, Anna Karolina Palucka · 2019 to 2026
$23.1M
Topological Mapping of Immune, Microbiota, Metabolomic and Clinical Phenotypes to Reveal ME/CFS Disease Mechanisms - Clinical Research ProjectU54NS105539 · NINDS · JACKSON LABORATORY · PI VERNON, SUZANNE D · 2017 to 2022
$10.6M
Metagenomes to Therapeutics: Defining the Rules for Engineering the Skin MicrobiomeDP2GM126893 · NIGMS · JACKSON LABORATORY · PI OH, JULIA · 2017 to 2017
$2.8M
Molecular Mechanisms of Staphylococcus Epidermidis Strain DiversityR01AR078634 · NIAMS · JACKSON LABORATORY · PI OH, JULIA · 2021 to 2025
$2.5M
Microbiome Plasticity and Pathogenicity in Older Adults: Baselines and Transitions from Skilled Nursing CareR56AG060746 · NIA · JACKSON LABORATORY · PI KUCHEL, GEORGE A, OH, JULIA · 2019 to 2019
$779k
Skin Microbiome of Monogenic Skin DisordersR21AR075174 · NIAMS · JACKSON LABORATORY · PI OH, JULIA · 2019 to 2022
$466k
Community organizing: Harnessing the interactions of the microbiome as a basis for novel therapeutic strategiesK22AI119231 · NIAID · JACKSON LABORATORY · PI OH, JULIA · 2016 to 2017
$270k
NIAID NIH HHS K22 AI119231NIAID NIH HHS U19 AI142733NIAMS NIH HHS R01 AR078634NIAMS NIH HHS R21 AR075174NIA NIH HHS R56 AG060746NIGMS NIH HHS DP2 GM126893NINDS NIH HHS U54 NS105539
6 · The paper itself

Abstract

An extraordinary biodiversity of bacteria, fungi, viruses, and even small multicellular eukaryota inhabit the human skin. Genomic innovations have accelerated characterization of this biodiversity both at a species as well as the subspecies, or strain level, which further imparts a tremendous genetic diversity to an individual's skin microbiome. In turn, these advances portend significant species- and strain-specificity in the skin microbiome's functional impact on cutaneous immunity, barrier integrity, aging, and other skin physiologic processes. Future advances in defining strain diversity, spatial distribution, and metabolic diversity for major skin species will be foundational for understanding the microbiome's essentiality to the skin ecosystem and for designing topical therapeutics that leverage or target the skin microbiome.

Indexed as

MicrobiotaBacteriaBiodiversityFungiHumansSkin

Identifiers

PMID36242896
PMCPMC9701184
OpenAlexW4306156187

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.