ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2022
Deep sequencing analysis of clinical samples from patients with acute infectious conjunctivitis during the COVID-19 delta surge in Madurai, India.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Use of Large Language Models to Classify Epidemiological Characteristics in Synthetic and Real-World Social Media Posts About Conjunctivitis Outbreaks: Infodemiology Study.Journal of medical Internet research · 2025Article
- SARS-CoV-2 positivity rates in tear secretions of inpatient COVID-positive individuals in an Indian tertiary care setting.Indian journal of ophthalmology · 2025Article
- Identification of coxsackievirus A24 variant during an acute hemorrhagic conjunctivitis outbreak in coastal Kenya, 2024.Wellcome open research · 2025Article
- Coxsackievirus A24 causing acute conjunctivitis in a 2023 outbreak in Vietnam.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024Article
- Use of Large Language Models to Assess the Likelihood of Epidemics From the Content of Tweets: Infodemiology Study.Journal of medical Internet research · 2024Article
- Comprehensive Profile of Pathogens and Antimicrobial Resistance in Conjunctivitis Cases from Niger.The American journal of tropical medicine and hygiene · 2023Article
- Adenoviral Conjunctivitis in the Andaman Islands: A Clinical and Molecular Epidemiological Study.Cureus · 2023Article
- Apollo Rising: Acute Conjunctivitis Outbreak in India, 2022.Cornea open · 2023Article
- Viruses Associated with Acute Conjunctivitis in Vanuatu.The American journal of tropical medicine and hygiene · 2023Article
- Outpatient human coronavirus associated conjunctivitis in India.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2022Article
- Acute haemorrhagic conjunctivitis outbreak attributed to coxsackievirus A24 in Ratanakiri, Cambodia, 2023.Western Pacific surveillance and response journal : WPSARArticle
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Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundSeasonal outbreaks of infectious conjunctivitis remain a public health issue. Determination of outbreak etiologies in the context of a worldwide pandemic may provide useful information to guide public health strategies. The aim of this study was to identify pathogens associated with outpatient infectious conjunctivitis during the COVID-19 Delta surge.
methodsThis prospective study was conducted from April 2021 to September 2021. All outpatients presenting to the Aravind Eye Center (Madurai, India) with signs and symptoms consistent with acute infectious conjunctivitis were eligible. Three swabs were obtained from each participant: one from each conjunctiva and one from the anterior nares. Samples were processed for metagenomic RNA deep sequencing (RNA-seq).
resultsSamples from 106 study participants were sequenced. The most common presenting symptoms were tearing (86%) and itching (71%). Preauricular lymphadenopathy was present in 38% of participants. 20% of participants had close contacts with similar symptoms. Systemic symptoms such as coughing, runny nose, vomiting or diarrhea were uncommonly reported. 60% of all participants used some medicated eye drops upon enrollment. 75% of study participants demonstrated infection with human adenovirus D (HAdV-D). 11% of conjunctivitis was associated with SARS-CoV-2. 15% had no definitive pathogen detected. 8% of all participants had codetection of more than one pathogen on RNA-seq.
conclusionsDuring the COVID-19 Delta surge in India, HAdV-D was the most common pathogen associated with infectious conjunctivitis. SARS-CoV-2 was the second most common associated pathogen. Seasonal surveillance may be necessary for the determination of emerging and reemerging pathogens responsible for infectious conjunctivitis.
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