ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2023
Results of the treatment of pineal tumors in children: the Lyon experience.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 9 citations in OpenAlex.
- Papillary Tumors of the Pineal Region (PTPR) in Pediatric Population: A Case Report and Literature Review.Asia-Pacific journal of clinical oncology · 2026Review
- Neoadjuvant chemotherapy for pineal region tumors.Journal of neuro-oncology · 2026Article
- The Infratentorial Supracerebellar Approach: The Most Used Avenue for Pineal and Pineal Region Tumors: How We Do It.Advances and technical standards in neurosurgery · 2026Article
- Decisional Tree for Pineal Tumors.Advances and technical standards in neurosurgery · 2026Review
- Surgery of Pineal and Pineal Region Tumours: The Sub-Occipital Transtentorial Approach for Pineal Tumours: How We Do It in Lyon.Advances and technical standards in neurosurgery · 2026Review
- Pineal Gland Parenchyma Tumors.Advances and technical standards in neurosurgery · 2026Review
- Conclusions.Advances and technical standards in neurosurgery · 2026Review
- Surgical characteristics and survival outcomes of pediatric pineal region tumors: a cohort study in Vietnam.Journal of neuro-oncology · 2025Article
- Optimal therapeutic strategies for pineal region lesions.Frontiers in neurology · 2023Article
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Authors and funding
8 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionPineal tumors are rare and their incidence is of 1% among all pediatric tumors of the central nervous system. Patient survival depends on the histology, the extension of the surgical removal, and the efficacy of the complementary treatment (chemotherapy and cranio-spinal irradiation), as well as the age of the patient. MATERIALS AND
methodsIn this study, we analyzed 151 pediatric patients treated for pineal tumors from 1997 to 2020 in Lyon, France. All patients were recorded in the French Register of Pineal tumors, which has been centralized and maintained in Lyon since 2010.
resultsOur analysis shows that benign tumors have an overall positive prognosis with total surgical removal. Concerning pineal parenchymal tumors, pinealoblastomas have a poor prognosis , especially in children less than three years old. A new pathological classification system allows for a better stratification of patient risk within different groups of patients with pineal tumors. It is also important to note that the identification of DICER 1 syndrome in families with pinealoblastomas warrant further medical investigation. Patients with Germ Cell Tumors have more favorable outcomes, with a global survival rate of 87 % and a pure germinoma survival rate of almost 97%. When analyzing the prognosis of pineal gland gliomas, otherwise known as tectal plate gliomas, pilocytic astrocytomas had a promising prognosis. Otherwise, prognosis of other tectal plate gliomas are related to the grade of malignancy and the efficacy of complementary treatment. Lastly, papillary tumors need a complete removal for the best chance of survival, and Atypical teratoid/ rabdoid tumors (AT/TR) still have a bad prognosis, regardless of surgical resection.
conclusionsOur results show that, with regards to pediatric pineal region tumors, there are still areas in prognostic indicators that need to be improved. Similarly, these pathologies need to be treated via a multidisciplinary approach to improve a patient's survival rate and their quality of life.
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