Evidence map›Paper›PMID 36242631›Full record

ArticleInternational urogynecology journal2023

Effectiveness of intravesical ozone in interstitial cystitis by the O'Leary-Sant symptom index.

Maria Verônica Pires, Carlos José de Lima, Henrique Cunha Carvalho, Lívia Helena Moreira, Adriana Barrinha Fernandes

2 registry-linked trialsOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International urogynecology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06863220 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Intravesical Ozone Therapy for Interstitial Cystitis/Bladder Pain Syndrome

TypeinterventionalSponsorMedipol UniversityRan2025 to 2026Enrolled60ConditionsInterstitial Cystitis, Bladder Pain SyndromeArmsIntravesical Ozone Therapy, Placebo (Normal Saline), Control
NCT07035522 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Evaluation of the Effects of Ozone Therapy on Endometriosis

TypeinterventionalSponsorUniversidade Federal do ParanáRan2025 to 2025Enrolled40ConditionsEndometriosis, Ozone Therapy, ThermographyArmsOzone therapy
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. [Interstitial cystitis/bladder pain syndrome (IC/BPS)].Urologie (Heidelberg, Germany) · 2023
    Review
  8. Review
  9. Clinical characteristics of patients with interstitial cystitis/bladder pain syndrome combined with migraine.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Maria Verônica PiresBiomedical Engineering Institute, Anhembi Morumbi University (UAM), Rua Casa do Ator, 275, São Paulo, SP, 04546-001, Brazil. mariaveronicapires46@gmail.com.ORCID http://orcid.org/0000-0002-2674-8047
Carlos José de LimaBiomedical Engineering Institute, Anhembi Morumbi University (UAM), Rua Casa do Ator, 275, São Paulo, SP, 04546-001, Brazil.ORCID https://orcid.org/0000-0001-6736-2100
Henrique Cunha CarvalhoCenter for Innovation, Technology, and Education (CITÉ), São José dos Campos Technological Park, Estrada Dr. Altino Bondensan, 500, São José dos Campos, SP, 12247-016, Brazil.ORCID https://orcid.org/0000-0003-0806-4132
Lívia Helena MoreiraBiomedical Engineering Institute, Anhembi Morumbi University (UAM), Rua Casa do Ator, 275, São Paulo, SP, 04546-001, Brazil.ORCID https://orcid.org/0000-0001-6432-7596
Adriana Barrinha FernandesBiomedical Engineering Institute, Anhembi Morumbi University (UAM), Rua Casa do Ator, 275, São Paulo, SP, 04546-001, Brazil.ORCID https://orcid.org/0000-0002-1794-0790
Anhembi Morumbi University · BRUniversidade Tecnológica Federal do Paraná · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introduction and hypothesisA prospective clinical, preliminary study was performed in patients with interstitial cystitis/bladder pain syndrome (IC/BPS) who were nonresponders to conventional treatment and received intravesical ozone as a therapeutic alternative.

methodsSixteen patients received six applications of intravesical ozone at a concentration of 41 μg/mL. We evaluated therapeutic efficacy by the percentage reduction of Interstitial Cystitis Symptom and Problem Index scores (ICSI/ICPI-the O'Leary-Sant symptom index), recurrence rate, nonresponse, and side effects in scores collected on admission (pre-treatment), at the end of the therapeutic protocol (post-treatment), and 180 days (follow-up) after the last ozone application.

resultsThe mean age of women was 52.9 years (SD: 15.5), and the duration of symptoms was 5.7 years (SD: 7.1). The median ICSI on admission was 17 (IQR: 14.25-19.5) and at follow-up was 0.5 (IQR: 0-2), with a reduction of 97.5% (CI: 85.7-100). The median ICSI/ICPI on admission was 31.5 (IQR: 29-35.2) and at follow-up was 2.0 (IQR: 0-3.75), with a reduction of 92.3% (CI: 88.8-100). The recurrence rate was only 6.25%, and no patients were nonresponders to the treatment.

conclusionsThe application of intravesical ozone was effective in the treatment of patients with IC/BPS who were nonresponders to conventional therapy, showing a progressive and safe effect, at least in the short term.

Indexed as

Cystitis, InterstitialAdministration, IntravesicalFemaleHumansMiddle AgedProspective StudiesTreatment OutcomeBladder pain syndromeInterstitial cystitisO'Leary–Sant symptom indexOzoneOzone therapy

Identifiers

PMID36242631
PMCPMC9569001
OpenAlexW4306292577

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.