ArticleBMC psychiatry2022
Association between childhood trauma and medication adherence among patients with major depressive disorder: the moderating role of resilience.
Article in BMC psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Metabolic markers in bipolar disorder with childhood trauma exposure: a systematic review.CNS spectrums · 2026Pooled it
- Exploring the Relationship Between Parental Trauma, Parenting Style, and Children's Medical Treatment Adherence: Cross-Sectional Study.JMIR formative research · 2026Article
- The intersection between race/ethnicity and adverse childhood experiences and its association with depression.Social psychiatry and psychiatric epidemiology · 2026Article
- The Role of Adverse Childhood Experiences in the Development of Major Depressive Disorder and Treatment-Resistant Depression.Child psychiatry and human development · 2026Review
- Perceived stigma, emotional resilience, and depressive/anxiety symptoms across school stages: a cross-sectional study.Frontiers in psychiatry · 2026Article
- The Impact of Smartphone Addiction on PTSD Symptoms Among South African University Students: Resilience as a Protective Factor.Healthcare (Basel, Switzerland) · 2025Article
- Combined lifestyle, childhood trauma and depressive symptoms in adults with subthreshold depression: a prospective cohort study.Epidemiology and psychiatric sciences · 2025Article
- Pathway from childhood trauma to nonsuicidal self-injury in adolescents with major depressive disorder: the chain-mediated role of psychological resilience and depressive severity.European archives of psychiatry and clinical neuroscience · 2024Article
- Associations between adverse childhood experiences and trust in health and other information from public services, professionals and wider sources: national cross sectional survey.BMJ public health · 2024Article
- Psychodynamically Informed Brain Stimulation: Building a Bridge from Brain to Mind.American journal of psychoanalysis · 2024Article
- Longitudinal Association between Stressful Life Events and Suicidal Ideation in Adults with Major Depression Disorder: The Mediating Effects of Insomnia Symptoms.Behavioral sciences (Basel, Switzerland) · 2024Article
- A prospective assessment of resilience in trauma patients using the Connor-Davidson Resilience Scale.Surgery · 2023Article
- Impact of childhood maltreatment on adult resilience.BMC psychiatry · 2023Article
- Regular cannabis use is associated with history of childhood and lifetime trauma in a non-clinical community sample.Journal of psychiatric research · 2023Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSuboptimal medication adherence is a major reason for failure in the management of major depressive disorder (MDD), childhood trauma might be an essential risk factor of suboptimal medication adherence. This study aimed to comprehensively explore the associations between different types of childhood trauma and medication adherence among patients with MDD, and to test whether resilience has moderating effects on the foregoing associations.
methodsParticipants were from the Depression Cohort in China (ChiCTR registry number 1900022145), 282 MDD patients with completed both baseline and 12-weeks follow-up investigations were included in this study. The diagnosis of MDD was assessed by trained psychiatrists using the Mini-International Neuropsychiatric Interview (M.I.N.I.). Childhood trauma was evaluated using the Childhood Trauma Questionnaire-28 item Short Form (CTQ-SF), and resilience was evaluated using the Connor-Davidson Resilience Scale (CD-RISC). Demographic characteristics, depression symptoms, anxiety symptoms, suicidal ideation, suicidal attempt, insomnia symptoms, and painful somatic symptoms were also investigated. Participants were divided into groups of optimal and suboptimal adherence based on their Medication Adherence Rating Scale scores. Logistic regression and stratified analyses were performed.
resultsA total of 234 participants (83%) reported suboptimal medication adherence. After adjusting for covariates, CTQ total scores (AOR = 1.03, 95%CI = 1.01-1.06), CTQ measures of sexual abuse (AOR = 1.17, 95%CI = 1.01-1.37), and CTQ measures of physical neglect (AOR = 1.12, 95%CI = 1.02-1.23) were all associated with an increased likelihood of suboptimal adherence. There were significant moderating effects of resilience on the associations of childhood trauma (P = 0.039) and physical neglect (P = 0.034) with medication adherence. The stratification analyses showed that CTQ total scores and CTQ measures of physical neglect were independently associated with an increased risk of suboptimal adherence among patients with MDD with low-resilience or moderate-resilience, while not significantly associated with suboptimal adherence in those with high-resilience.
conclusionChildhood trauma was a significant risk factor of suboptimal adherence among patients with MDD, and resilience moderated the foregoing association. Obtaining a history of childhood trauma and assessing resilience may help identify patients with suboptimal adherence when providing MDD pharmacotherapy. Psychiatrists may consider enhancing resilience to cope with the adverse effects of childhood trauma on medication adherence.
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