Evidence map›Paper›PMID 36241911›Full record

ArticleCommunications biology2022

Rapid differentiation of hiPSCs into functional oligodendrocytes using an OLIG2 synthetic modified messenger RNA.

Jian Xu, Zhihua Yang, Rui Wang, Fumei He, Rong Yan, Yidi Zhang, Liying Yu, Wenbin Deng, Yichu Nie

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Jian Xu *School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, China.ORCID 0000-0003-2552-2553
Zhihua Yang *Stroke Center, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510799, China.ORCID 0000-0001-9172-399X
Rui Wang *Clinical Research Institute, The First People's Hospital of Foshan, Foshan, 528000, China.
Fumei HeSchool of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, China.
Rong YanClinical Research Institute, The First People's Hospital of Foshan, Foshan, 528000, China.
Yidi ZhangSchool of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, China.
Liying YuStroke Center, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510799, China.
Wenbin DengSchool of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, China. dengwb5@mail.sysu.edu.cn.ORCID 0000-0002-8897-4891
Yichu NieSchool of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, China. nieyichu2@126.com.ORCID 0000-0002-6746-2598
Sun Yat-sen University · CNFirst People's Hospital of Foshan · CNGuangzhou Medical University · CNShenzhen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcription factors (TFs) have been introduced to drive the highly efficient differentiation of human-induced pluripotent stem cells (hiPSCs) into lineage-specific oligodendrocytes (OLs). However, effective strategies currently rely mainly on genome-integrating viruses. Here we show that a synthetic modified messenger RNA (smRNA)-based reprogramming method that leads to the generation of transgene-free OLs has been developed. An smRNA encoding a modified form of OLIG2, in which the serine 147 phosphorylation site is replaced with alanine, OLIG2

Indexed as

Induced Pluripotent Stem CellsNeurodegenerative DiseasesAlanineHumansOligodendrocyte Transcription Factor 2OligodendrogliaRNA, MessengerSerineTranscription FactorsAlanineOLIG2 protein, humanOligodendrocyte Transcription Factor 2RNA, MessengerSerineTranscription Factors

Identifiers

PMID36241911
PMCPMC9568531
OpenAlexW4306179661

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.