Evidence map›Paper›PMID 36241855›Full record

ReviewRadiation and environmental biophysics2022

Radiation dose rate effects: what is new and what is needed?

Donna Lowe, Laurence Roy, Maria Antonella Tabocchini, Werner Rühm, Richard Wakeford, Gayle E Woloschak, Dominique Laurier

Abstract readReview
In one paragraph

Review in Radiation and environmental biophysics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Review
  2. Article
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  8. Sexual dimorphism inScientific reports · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Creating largeFrontiers in plant science · 2025
    Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Donna LoweUK Health Security Agency, CRCE Chilton, Didcot, OX11 0RQ, Oxfordshire, UK.
Laurence RoyInstitut de Radioprotection Et de Sûreté Nucléaire, Fontenay-Aux-Roses, France.
Maria Antonella TabocchiniIstituto Nazionale i Fisica Nucleare, Sezione i Roma, Rome, Italy.
Werner RühmInstitute of Radiation Medicine, Helmholtz Center Munich, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.
Richard WakefordCentre for Occupational and Environmental Health, The University of Manchester, Manchester, M13 9PL, UK.
Gayle E WoloschakDepartment of Radiation Oncology, Northwestern University School of Medicine, Chicago, IL, USA. g-woloschak@northwestern.edu.
Dominique LaurierInstitut de Radioprotection Et de Sûreté Nucléaire, Fontenay-Aux-Roses, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite decades of research to understand the biological effects of ionising radiation, there is still much uncertainty over the role of dose rate. Motivated by a virtual workshop on the "Effects of spatial and temporal variation in dose delivery" organised in November 2020 by the Multidisciplinary Low Dose Initiative (MELODI), here, we review studies to date exploring dose rate effects, highlighting significant findings, recent advances and to provide perspective and recommendations for requirements and direction of future work. A comprehensive range of studies is considered, including molecular, cellular, animal, and human studies, with a focus on low linear-energy-transfer radiation exposure. Limits and advantages of each type of study are discussed, and a focus is made on future research needs.

Indexed as

Radiation ExposureRadiation InjuriesRadiation ProtectionAnimalsHumansRadiation DosageRadiation, IonizingRadiobiologyDose rateEpidemiologyIonising radiationLow-LETRadiobiologyRecommendations

Identifiers

PMID36241855
PMCPMC9630203

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.