Evidence map›Paper›PMID 36241661›Full record

ArticleScientific reports2022

Isolation and characterization of an anti-proliferative polysaccharide from the North American fungus Echinodontium tinctorium.

Mehreen Zeb, Wai Ming Li, Christian Heiss, Ian Black, Linda E Tackaberry, Hugues B Massicotte, Keith N Egger, Kerry Reimer, Parastoo Azadi, Chow H Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Antiproliferative Fatty Acids Isolated from the Polypore FungusJournal of fungi (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Mehreen ZebDepartment of Chemistry and Biochemistry, Faculty of Science and Engineering, University of Northern British Columbia, Prince George, BC, V2N 4Z9, Canada.
Wai Ming LiDepartment of Chemistry and Biochemistry, Faculty of Science and Engineering, University of Northern British Columbia, Prince George, BC, V2N 4Z9, Canada.
Christian HeissComplex Carbohydrate Research Center, University of Georgia, Athens, GA, 30602, USA.
Ian BlackComplex Carbohydrate Research Center, University of Georgia, Athens, GA, 30602, USA.
Linda E TackaberryDepartment of Ecosystem Science and Management, Faculty of Environment, University of Northern British Columbia, Prince George, BC, V2N 4Z9, Canada.
Hugues B MassicotteDepartment of Ecosystem Science and Management, Faculty of Environment, University of Northern British Columbia, Prince George, BC, V2N 4Z9, Canada.
Keith N EggerDepartment of Ecosystem Science and Management, Faculty of Environment, University of Northern British Columbia, Prince George, BC, V2N 4Z9, Canada.
Kerry ReimerDepartment of Chemistry and Biochemistry, Faculty of Science and Engineering, University of Northern British Columbia, Prince George, BC, V2N 4Z9, Canada.
Parastoo AzadiComplex Carbohydrate Research Center, University of Georgia, Athens, GA, 30602, USA.
Chow H LeeDepartment of Chemistry and Biochemistry, Faculty of Science and Engineering, University of Northern British Columbia, Prince George, BC, V2N 4Z9, Canada. chow.lee@unbc.ca.
University of Northern British Columbia · CAUniversity of Georgia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel polysaccharide EtGIPL1a was purified from fruiting bodies of Echinodontium tinctorium, a fungus unique to western North America. EtGIPL1a has an estimated weight average molecular weight of 275 kDa and is composed of glucose (54.3%), galactose (19.6%), mannose (11.1%), fucose (10.3%), glucuronic acid (4%), and rhamnose (0.6%). It has multiple glycosidic linkages, with 3-Glcp (28.9%), 6-Glcp (18.3%), 3,6-Glcp (13%), 4-GlcpA (9.2%), 6-Galp (3.9%), 2,6-Galp (2.6%), 3-Fucp (2.5%), 6-Manp (2.4%) being the most prominent, and unsubstituted glucose (15.3%), mannose (1.3%) and fucose (0.9%) as major terminal sugars. EtGIPL1a has a backbone containing mostly 3-substituted β-glucopyranose with 4-substituted glucopyranosyluronic acid. EtGIPL1a showed anti-proliferative activity against multiple cancer cell lines, with IC

Indexed as

BasidiomycotaGalactoseAnimalsFucoseGlucoseGlucuronic AcidMannoseMolecular WeightPolysaccharidesRhamnoseFucoseGalactoseGlucoseGlucuronic AcidMannosePolysaccharidesRhamnose

Identifiers

PMID36241661
PMCPMC9568501
OpenAlexW4306249690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.