ArticleNature communications2022
Alignment of single-cell trajectory trees with CAPITAL.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- A novel paradigm for single-cell annotation in stem cell research.Stem cell reports · 2025Review
- Single-cell proteomics using mass spectrometry.Cell genomics · 2025Review
- PSCS: Unified Sharing of Single-Cell Omics Data, Analyses, and Results.Journal of proteome research · 2025Article
- Cross-species comparison reveals therapeutic vulnerabilities halting glioblastoma progression.Nature communications · 2025Article
- Single-Cell and Bulk RNA Sequencing Highlights Intra-Tumoral Heterogeneity and Malignant Progression Mechanisms in Prostate Cancer.Journal of cellular and molecular medicine · 2025Article
- scRL: Utilizing Reinforcement Learning to Evaluate Fate Decisions in Single-Cell Data.Biology · 2025Article
- Article
- Trajectory Inference for Single Cell Omics.ArXiv · 2025Article
- Gene-level alignment of single-cell trajectories.Nature methods · 2025Article
- Distributed Collaboration for Data, Analysis Pipelines, and Results in Single-Cell Omics.bioRxiv : the preprint server for biology · 2024Article
- DELVE: feature selection for preserving biological trajectories in single-cell data.Nature communications · 2024Article
- Bringing CAM photosynthesis to the table: Paving the way for resilient and productive agricultural systems in a changing climate.Plant communications · 2024Review
- Principled and interpretable alignability testing and integration of single-cell data.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Decoding Human Biology and Disease Using Single-cell Omics Technologies.Genomics, proteomics & bioinformatics · 2023Review
- Feature selection for preserving biological trajectories in single-cell data.bioRxiv : the preprint server for biology · 2023Article
- Omics data integration in computational biology viewed through the prism of machine learning paradigms.Frontiers in bioinformatics · 2023Review
- Alignment of single-cell trajectory trees with CAPITAL.Nature communications · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Global alignment of complex pseudotime trajectories between different single-cell RNA-seq datasets is challenging, as existing tools mainly focus on linear alignment of single-cell trajectories. Here we present CAPITAL (comparative analysis of pseudotime trajectory inference with tree alignment), a method for comparing single-cell trajectories with tree alignment whereby branching trajectories can be automatically compared. Computational tests on synthetic datasets and authentic bone marrow cells datasets indicate that CAPITAL has achieved accurate and robust alignments of trajectory trees, revealing various gene expression dynamics including gene-gene correlation conservation between different species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.