Evidence map›Paper›PMID 36241643›Full record

ArticleNature communications2022

Structure of the core human NADPH oxidase NOX2.

Sigrid Noreng, Naruhisa Ota, Yonglian Sun, Hoangdung Ho, Matthew Johnson, Christopher P Arthur, Kellen Schneider, Isabelle Lehoux, Christopher W Davies, Kyle Mortara and 6 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 94 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Oxidative Stress and Redox Imbalance inInternational journal of molecular sciences · 2026
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  8. Fungal Infections in Disorders of Inborn Errors of Immunity.Clinical reviews in allergy & immunology · 2026
    Review
  9. Article
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  11. Review
  12. Article
  13. The role of neutrophils in the pathogenesis of abdominal aortic aneurysms.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  14. Article
  15. Article
  16. Nitrogen-Boosted HAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  17. Review
  18. Article
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 2 countries.

Sigrid Noreng *Department of Structural Biology, Genentech Inc., South San Francisco, CA, 94080, USA.ORCID 0000-0001-5767-1399
Naruhisa Ota *Department of Immunology, Genentech Inc., South San Francisco, CA, 94080, USA.ORCID 0000-0001-6663-7336
Yonglian Sun *Department of Antibody Engineering, Genentech Inc., South San Francisco, CA, 94080, USA.
Hoangdung HoDepartment of Structural Biology, Genentech Inc., South San Francisco, CA, 94080, USA.
Matthew JohnsonDepartment of Structural Biology, Genentech Inc., South San Francisco, CA, 94080, USA.
Christopher P ArthurDepartment of Structural Biology, Genentech Inc., South San Francisco, CA, 94080, USA.
Kellen SchneiderDepartment of Antibody Engineering, Genentech Inc., South San Francisco, CA, 94080, USA.
Isabelle LehouxDepartment of Biomolecular Resources, Genentech Inc., South San Francisco, CA, 94080, USA.
Christopher W DaviesDepartment of Antibody Engineering, Genentech Inc., South San Francisco, CA, 94080, USA.ORCID 0000-0001-9559-438X
Kyle MortaraDepartment of Biomolecular Resources, Genentech Inc., South San Francisco, CA, 94080, USA.
Kit WongDevSci OMNI-Biomarker Development, Genentech Inc., South San Francisco, CA, 94080, USA.
Dhaya SeshasayeeDepartment of Antibody Engineering, Genentech Inc., South San Francisco, CA, 94080, USA.
Matthieu MasureelDepartment of Structural Biology, Genentech Inc., South San Francisco, CA, 94080, USA. masureel.matthieu@gene.com.ORCID 0000-0002-4059-6166
Jian PayandehDepartment of Structural Biology, Genentech Inc., South San Francisco, CA, 94080, USA. jpayandeh@exelixis.com.ORCID 0000-0002-4015-9716
Tangsheng YiDepartment of Immunology, Genentech Inc., South San Francisco, CA, 94080, USA. tangshengy@gmail.com.ORCID 0000-0002-2959-4979
James T KoerberDepartment of Antibody Engineering, Genentech Inc., South San Francisco, CA, 94080, USA. koerber.james@gene.com.ORCID 0000-0001-7756-972X
Codexis (United States) · USExelixis (United States) · USFrontier Aerospace Corporation (United States) · USGenesys (United States) · USGene Therapy Laboratory · FRProtein Express (United States) · USTanglewood Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NOX2 is the prototypical member of the NADPH oxidase NOX superfamily and produces superoxide (O

Indexed as

NADPH OxidasesSuperoxidesHumansImmunoglobulin FragmentsNADPH Oxidase 2Reactive Oxygen SpeciesCYBB protein, humanImmunoglobulin FragmentsNADPH Oxidase 2NADPH OxidasesReactive Oxygen SpeciesSuperoxides

Identifiers

PMID36241643
PMCPMC9568551
OpenAlexW4306175378

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.