ArticleIn vitro cellular & developmental biology : journal of the Tissue Culture Association1987
In vitro modulation of antioxidant enzymes in normal and malignant renal epithelium.
Article in In vitro cellular & developmental biology : journal of the Tissue Culture Association, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 25 citations in OpenAlex.
- Immunohistochemical localization of antioxidant enzymes during hamster kidney development.The Histochemical journal · 1995Article
- Immunolocalization of antioxidant enzymes in adult hamster kidney.The Histochemical journal · 1994Article
- Immunogold analysis of antioxidant enzymes in human renal cell carcinoma.Virchows Archiv : an international journal of pathology · 1994Article
- Immunohistochemical localization of glutathione-S-transferase and glutathione peroxidase in adult Syrian hamster tissues and during kidney development.The American journal of pathology · 1991Article
- Effect of cell substrate on antioxidant enzyme activities in cultured renal glomerular epithelium.The American journal of pathology · 1988Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The activities of three antioxidant enzymes, superoxide dismutase, catalase, and glutathione peroxidase, were monitored in isolated human renal adenocarcinoma tissues and in cultured human renal adenocarcinoma cells. The results were compared to the activities of these enzymes in the proposed cell of origin, isolated human proximal tubular tissues, and cultured proximal tubular epithelial cells. Strong modulation of these enzymes by culture conditions was observed in normal cells but not in carcinoma cells. Low levels of cellular lipid peroxidation, as assessed by levels of malondialdehyde (MDA), were observed in adenocarcinoma cells under the culture conditions tested with one exception: greatly elevated MDA was observed in renal adenocarcinoma cells grown on plastic in serum-free, chemically defined medium. This increased lipid peroxidation correlated with a loss of cell viability under these conditions.
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