Evidence map›Paper›PMID 36241363›Full record

SynthesisAnnals of the rheumatic diseases2023

Global epidemiology of systemic lupus erythematosus: a comprehensive systematic analysis and modelling study.

Jingru Tian, Dingyao Zhang, Xu Yao, Yaqing Huang, Qianjin Lu

Registry-linked trialOpen access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Annals of the rheumatic diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06586359 (Evaluation of Bone Mineral Density in Patients With Childhood-onset Systemic Lupus Erythematous, in Relation to Disease Clinical Criteria), which is not on this map. Cited by 332 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
332citing papers in PubMed, 18 pooled it
77.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06586359 not yet recruitingnot on this mapstarted 2024, after this paper: background citation

Evaluation of Bone Mineral Density in Patients With Childhood-onset Systemic Lupus Erythematous, in Relation to Disease Clinical Criteria

TypeobservationalSponsorAssiut UniversityRan2024 to 2026Enrolled78ConditionsSystemic Lupus Erthematosus
3 · Its place in the literature

Who cites it

332 citing papers in PubMed, 18 syntheses or guidelines pooled it, 506 citations in OpenAlex.

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  3. Genome-wide meta-analysis with 1,590,596 individuals identifies 12 novel risk loci for systemic lupus erythematosus.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
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272 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jingru TianInstitute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Dingyao ZhangGraduate Program in Biological and Biomedical Sciences, Yale University, New Haven, Connecticut, USA.
Xu YaoInstitute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Yaqing HuangDepartment of Pathology, Yale University, New Haven, Connecticut, USA.
Qianjin LuInstitute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China qianlu5860@pumcderm.cams.cn.ORCID 0000-0002-4192-4897
Chinese Academy of Medical Sciences & Peking Union Medical College · CNYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo quantify global, regional and country-specific estimates of epidemiology of systemic lupus erythematosus (SLE).

methodsFour databases were systematically searched, and a Bayesian hierarchical linear mixed model was constructed to estimate the global, regional, and country-specific incidence and prevalence of SLE.

results112 studies met the inclusion criteria. The global SLE incidence and newly diagnosed population were estimated to be 5.14 (1.4 to 15.13) per 100 000 person-years and 0.40 million people annually, respectively. In women, the values were 8.82 (2.4 to 25.99) per 100 000 person-years and 0.34 million people annually, while in men, the estimates were 1.53 (0.41 to 4.46) per 100 000 person-years and 0.06 million people annually, respectively. Poland, the USA and Barbados had the highest estimates of SLE incidence. Regarding prevalence, the global SLE prevalence and affected population were estimated to be 43.7 (15.87 to 108.92) per 100 000 persons and 3.41 million people, respectively. In women, the values were 78.73 (28.61 to 196.33) per 100 000 persons and 3.04 million people, while in men the estimates were 9.26 (3.36 to 22.97) per 100 000 persons and 0.36 million people, respectively. The United Arab Emirates, Barbados and Brazil had the highest SLE prevalence. In addition to regional and sex differences, age and prevalence estimation method (period or point prevalence) differences could also lead to variations in epidemiological SLE findings.

conclusionsEpidemiological data on SLE are lacking for 79.8% of countries worldwide. The epidemiology of SLE varies substantially between different sex and age groups and is distributed unequally among geographical regions; specifically, SLE occurs more frequently in high-income countries.

Indexed as

Lupus Erythematosus, SystemicBayes TheoremFemaleHumansIncidenceMalePolandPrevalenceAutoimmune DiseasesEpidemiologySystemic Lupus Erythematosus

Identifiers

PMID36241363
PMCPMC9933169
OpenAlexW4306181506

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.